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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Several lines of evidence suggest that a genetic component underlies Tourette's syndrome (TS). We investigated both the role of the insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and that of the Val-158-Met substitution in the catechol-O-methyl-transferase (COMT) gene in conferring susceptibility to TS. Fifty-two TS patients were recruited and compared with a control group of 63 healthy subjects. Neither a genotypic nor an allelic association was found; subdividing TS patients according to clinical variables, such as a co-diagnosis of obsessive-compulsive disorder (OCD) and a positive family history for obsessive compulsive disorder or tics, also failed to reveal a significant association. The lack of significance for 5-HTTLPR and COMT polymorphisms in conferring liability to TS does not exclude a role of different functional polymorphisms in genes coding for serotonergic or dopaminergic structures in the etiology of TS. In fact, TS is a complex disorder and these genes most likely have only a minor genetic effect in its etiology.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0165-1781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-100
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11166081-Adult,
pubmed-meshheading:11166081-Alleles,
pubmed-meshheading:11166081-Carrier Proteins,
pubmed-meshheading:11166081-Catechol O-Methyltransferase,
pubmed-meshheading:11166081-DNA Primers,
pubmed-meshheading:11166081-Female,
pubmed-meshheading:11166081-Gene Expression,
pubmed-meshheading:11166081-Genetic Predisposition to Disease,
pubmed-meshheading:11166081-Genetic Variation,
pubmed-meshheading:11166081-Humans,
pubmed-meshheading:11166081-Male,
pubmed-meshheading:11166081-Membrane Glycoproteins,
pubmed-meshheading:11166081-Membrane Transport Proteins,
pubmed-meshheading:11166081-Nerve Tissue Proteins,
pubmed-meshheading:11166081-Obsessive-Compulsive Disorder,
pubmed-meshheading:11166081-Polymerase Chain Reaction,
pubmed-meshheading:11166081-Polymorphism, Genetic,
pubmed-meshheading:11166081-Promoter Regions, Genetic,
pubmed-meshheading:11166081-Serotonin,
pubmed-meshheading:11166081-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:11166081-Tourette Syndrome
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pubmed:year |
2000
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pubmed:articleTitle |
An association study between 5-HTTLPR polymorphism, COMT polymorphism, and Tourette's syndrome.
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pubmed:affiliation |
Istituto Scientifico H San Raffaele, Department of Neuroscience, University of Milan Medical School, Via L. Prinetti, 29, 20127, Milan, Italy. cavallini.cristina@hsr.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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