Linked Life Data

11166064

Source:http://linkedlifedata.com/resource/pubmed/id/11166064

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-2-22
pubmed:abstractText
The study in an ethological perspective of inbred strains of mice offers a more accurate description of anxiety-related behavior. In this context, behavioral performances of the BALB/cByJ and C57BL/6J strains were systematically compared in the staircase test, the light/dark test and the elevated plus maze test. A rarely used variable, the latency of the first entry in the dark box, was also recorded in the light/dark test. A new statistical approach to this measure meant that specific avoidance strategies could be differentiated in the two strains. A study of the behavioral responses of the two strains given treatment with diazepam, a widely used anxiolytic compound, was also carried out. Results showed substantial differences between BALB/cByJ and C57BL/6J strains. C57BL/6J mice had high baseline activity and exploration of a new environment, suggesting a low level of anxiety. BALB/cByJ mice displayed defensive and protective behavior, with limited exploration of the new environment together with low locomotor activity. The response to diazepam was also different for each strain: C57BL/6J mice showed higher sensitivity to diazepam treatment than did BALB/cByJ mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
739-48
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice.
pubmed:affiliation
CNRS UMR 7593, "Personnalité et conduites adaptatives", CHU Pitié-Salpêtrière, 91, Bd de l'Hôpital, 75013, Paris, France. lepicard@ext.jussieu.fr
pubmed:publicationType
Journal Article