Linked Life Data

11165475

Source:http://linkedlifedata.com/resource/pubmed/id/11165475

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-2-22
pubmed:abstractText
We are interested in the early mechanisms that initiate regional patterning in the dorsal telencephalon, which gives rise to cerebral cortex. Members of the LIM-homeodomain (LIM-HD) family of transcription factors are implicated in patterning and cell fate specification in several systems including the mammalian forebrain. Mice in which Lhx2 is disrupted were reported to have reduced telencephalic development, and the hippocampal primordium appeared to be missing, by morphological observation. We hypothesized that this may be due to a defect in the cortical hem, a Wnt- and Bmp-rich putative signaling center in the medial telencephalon, a source of regulatory signals for hippocampal development. We asked if the expression of any known hem-specific signaling molecule is deficient in Lhx2-/- mice. Our results reveal, unexpectedly, that at embryonic day (E)12.5, what appears to be some spared 'lateral' cortex is instead an expanded cortical hem. Normally restricted to the extreme medial edge of the telencephalon, the hem covers almost the entire dorsal telencephalon in the Lhx2-/- mice. This indicates a role for Lhx2 in the regulation of the extent of the cortical hem. In spite of an expanded, mislocated hem in the Lhx2-/- telencephalon, a potential source of ectopic dorsalizing cues, no hippocampal differentiation is detected in tissue adjacent to the mutant hem, nor does the overall dorsoventral patterning appear perturbed. We propose that Lhx2 is involved at a crucial early step in patterning the telencephalon, where the neuroepithelium is first divided into presumptive cortical tissue, and the cortical hem. The defect in the Lhx2-/- telencephalon appears to be at this step.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-75
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11165475-Animals, pubmed-meshheading:11165475-Cell Lineage, pubmed-meshheading:11165475-Cerebral Cortex, pubmed-meshheading:11165475-Choroid Plexus, pubmed-meshheading:11165475-Gene Expression Regulation, Developmental, pubmed-meshheading:11165475-Genotype, pubmed-meshheading:11165475-Hippocampus, pubmed-meshheading:11165475-Homeodomain Proteins, pubmed-meshheading:11165475-Homozygote, pubmed-meshheading:11165475-Immunohistochemistry, pubmed-meshheading:11165475-LIM-Homeodomain Proteins, pubmed-meshheading:11165475-Mice, pubmed-meshheading:11165475-Multigene Family, pubmed-meshheading:11165475-Protein Structure, Tertiary, pubmed-meshheading:11165475-Proto-Oncogene Proteins, pubmed-meshheading:11165475-Signal Transduction, pubmed-meshheading:11165475-Telencephalon, pubmed-meshheading:11165475-Time Factors, pubmed-meshheading:11165475-Transcription Factors, pubmed-meshheading:11165475-Wnt Proteins, pubmed-meshheading:11165475-Zebrafish Proteins
pubmed:year
2001
pubmed:articleTitle
LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem.
pubmed:affiliation
Department of Biological Sciences, Tata Institute of Fundamental Research, 400005, Mumbai, India.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't