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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
The valine (V) to leucine (L) polymorphism of the SRD5A2 gene is associated with 5-alpha reductase-2 activity; patients with the V allele have high activity and patients with the L allele have low activity. We examined whether this polymorphism predicts the presence of prostate cancer in 320 men without cancer who underwent biopsy and cancer progression in 318 men who underwent radical prostatectomy.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1527-9995
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-204
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11164181-Aged,
pubmed-meshheading:11164181-Alleles,
pubmed-meshheading:11164181-Cholestenone 5 alpha-Reductase,
pubmed-meshheading:11164181-Disease Progression,
pubmed-meshheading:11164181-Follow-Up Studies,
pubmed-meshheading:11164181-Genetic Markers,
pubmed-meshheading:11164181-Humans,
pubmed-meshheading:11164181-Leucine,
pubmed-meshheading:11164181-Male,
pubmed-meshheading:11164181-Middle Aged,
pubmed-meshheading:11164181-Neoplasm Proteins,
pubmed-meshheading:11164181-Neoplasm Recurrence, Local,
pubmed-meshheading:11164181-Odds Ratio,
pubmed-meshheading:11164181-Oxidoreductases,
pubmed-meshheading:11164181-Phenotype,
pubmed-meshheading:11164181-Polymorphism, Genetic,
pubmed-meshheading:11164181-Prostatic Neoplasms,
pubmed-meshheading:11164181-Valine
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pubmed:year |
2001
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pubmed:articleTitle |
V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression.
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pubmed:affiliation |
Division of Urology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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