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pubmed:otherAbstract |
PIP: A study was undertaken to determine whether alpha-chlorohydrin affects the metabolism of spermatozoa directly or through disruption of the metabolism of the eipdidymal tissue in the caudal region of the duct after a single high-dose injection in mature rats. A number of physiological studies were also conducted to determine whether damage was localized to the reproductive tract or of a more general nature. Oxygen uptake, glucose utilization, and lactic acid accumulation were reduced in the spermatozoa obtained from the cauda epididymis 48 and 240 hours after alpha-chlorohydrin injection (90 mg/kg). Motility of the spermatozoa was also significantly decreased. The results indicated that alpha-chlorohydrin had very little effect on the respiratory activity of the flushed epididymal tubule, liver, or kindey tissue, but it did stimulate glycolysis in the kidney. It appeared that the metabolic effects of alpha-chlorohydrin were fairly specifically confined to the spermatozoa in the epididymis. The drug at the high dosage did cause a loss of body weight, hypertrophy of the adrenal glands, and an increase in the total leukocyte count.
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