Source:http://linkedlifedata.com/resource/pubmed/id/11163610
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
The different concepts of impulsivity cover a wide range of divergent behaviors. In clinical terms, aspects of impulsivity are both an important feature in several psychiatric conditions related to a low central serotonergic neurotransmission like aggressive behavior and suicidality, and a core symptom of frontal lobe syndromes of various etiologies. Assessment of the different forms of impulsivity so far relies on clinical observations and self-rating questionnaires. Measurements of a distinct brain function associated with impulsive behavior are not available yet, however, electrophysiological parameters of cognitive response control elicited with the execution (Go-condition) and the inhibition (NoGo-condition) of a prepared motor response within the Continuous Performance Test (CPT) might be suitable candidates. By means of a spatial analysis method the centers of gravity (centroids) of the brain electrical fields evoked with Go- and NoGo-responses can be localized and quantified. In the present study, the Go- and NoGo-centroids and the impulsivity score in Eysenck's I(7)-scale were determined in 22 healthy subjects (10 women, 12 men, mean age 42.0+/-10.1 years). Impulsivity was correlated with both, a more anterior location of the Go- (r=0.58, P<0.01) and the NoGo-centroid (r=0.53, P=0.01). These results indicate, that in healthy subjects the amount of I(7)-impulsivity is associated with differences in the prefrontal brain activation pattern during cognitive response control. However, a replication study with a larger sample and an investigation of psychiatric patients with pathological levels of impulsivity are necessary to qualify these topographical ERP-parameters of cognitive response control as valid measures of the brain electrical basis of impulsive behavior.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0028-3932
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
328-33
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:11163610-Adult,
pubmed-meshheading:11163610-Cognition,
pubmed-meshheading:11163610-Electroencephalography,
pubmed-meshheading:11163610-Female,
pubmed-meshheading:11163610-Humans,
pubmed-meshheading:11163610-Impulsive Behavior,
pubmed-meshheading:11163610-Inhibition (Psychology),
pubmed-meshheading:11163610-Male,
pubmed-meshheading:11163610-Middle Aged,
pubmed-meshheading:11163610-Prefrontal Cortex,
pubmed-meshheading:11163610-Serotonin
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pubmed:year |
2001
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pubmed:articleTitle |
Electrophysiological assessment of impulsive behavior in healthy subjects.
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pubmed:affiliation |
Psychiatric Neurophysiology, Department of Psychiatry and Psychotherapy, University Hospital of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany. afallgat@mail.uni-wuerzburg.de
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pubmed:publicationType |
Journal Article
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