Source:http://linkedlifedata.com/resource/pubmed/id/11163460
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2001-2-22
|
| pubmed:abstractText |
Influenza A virus causes respiratory tract infections, which are occasionally complicated by secondary bacterial infections. Influenza A virus replicates in epithelial cells and leukocytes resulting in the production of chemokines and cytokines, which favor the extravasation of blood mononuclear cells and the development of antiviral and Th1-type immune response. Influenza A virus-infected respiratory epithelial cells produce limited amounts of chemokines (RANTES, MCP-1, IL-8) and IFN-alpha/beta, whereas monocytes/macrophages readily produce chemokines such as RANTES, MIP-1alpha, MCP-1, MCP-3, IP-10 and cytokines TNF-alpha, IL-1beta, IL-6, IL-18 and IFN-alpha/beta. The role of influenza A virus-induced inflammatory response in relation to otitis media is being discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0264-410X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
19 Suppl 1
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S32-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11163460-Apoptosis,
pubmed-meshheading:11163460-Bacterial Infections,
pubmed-meshheading:11163460-Cytokines,
pubmed-meshheading:11163460-Epithelium,
pubmed-meshheading:11163460-Gene Expression Regulation, Viral,
pubmed-meshheading:11163460-Humans,
pubmed-meshheading:11163460-Inflammation,
pubmed-meshheading:11163460-Influenza, Human,
pubmed-meshheading:11163460-Influenza A virus,
pubmed-meshheading:11163460-Interferon-alpha,
pubmed-meshheading:11163460-Macrophages,
pubmed-meshheading:11163460-Models, Biological,
pubmed-meshheading:11163460-Otitis Media,
pubmed-meshheading:11163460-Superinfection,
pubmed-meshheading:11163460-Th1 Cells,
pubmed-meshheading:11163460-Transcription, Genetic,
pubmed-meshheading:11163460-Transcription Factors,
pubmed-meshheading:11163460-Virus Replication
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Inflammatory responses in influenza A virus infection.
|
| pubmed:affiliation |
Department of Virology, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. ilkka.julkunen@ktl.fi
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|