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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide ("pep2-SVKI") into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings. Pep2-SVKI, but not a control or PICK1 selective peptide, caused AMPAR-mediated EPSC amplitude to increase in approximately one-third of control neurons and in most neurons following the prior induction of LTD. Pep2-SVKI also blocked LTD; however, this occurred in all neurons. A PKC inhibitor prevented these effects of pep2-SVKI on synaptic transmission and LTD. We propose a model in which the maintenance of LTD involves the binding of AMPARs to PDZ proteins to prevent their reinsertion. We also present evidence that PKC regulates AMPAR reinsertion during dedepression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Grip1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Grip1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prkcabp protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
873-86
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11163273-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11163273-Amino Acid Motifs,
pubmed-meshheading:11163273-Amyloid beta-Peptides,
pubmed-meshheading:11163273-Animals,
pubmed-meshheading:11163273-Carrier Proteins,
pubmed-meshheading:11163273-Cells, Cultured,
pubmed-meshheading:11163273-Enzyme Inhibitors,
pubmed-meshheading:11163273-Excitatory Postsynaptic Potentials,
pubmed-meshheading:11163273-Hippocampus,
pubmed-meshheading:11163273-Models, Neurological,
pubmed-meshheading:11163273-Nerve Tissue Proteins,
pubmed-meshheading:11163273-Neural Inhibition,
pubmed-meshheading:11163273-Neuronal Plasticity,
pubmed-meshheading:11163273-Nuclear Proteins,
pubmed-meshheading:11163273-Patch-Clamp Techniques,
pubmed-meshheading:11163273-Protein Kinase C,
pubmed-meshheading:11163273-Protein Structure, Tertiary,
pubmed-meshheading:11163273-Pyramidal Cells,
pubmed-meshheading:11163273-Rats,
pubmed-meshheading:11163273-Receptors, AMPA,
pubmed-meshheading:11163273-Recombinant Fusion Proteins,
pubmed-meshheading:11163273-Synaptic Transmission
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pubmed:year |
2000
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pubmed:articleTitle |
PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
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pubmed:affiliation |
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, BS8 1TD, Bristol, United Kingdom.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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