|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2001-2-22
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
We cloned the C. elegans gene ced-1, which is required for the engulfment of cells undergoing programmed cell death. ced-1 encodes a transmembrane protein similar to human SREC (Scavenger Receptor from Endothelial Cells). We showed that ced-1 is expressed in and functions in engulfing cells. The CED-1 protein localizes to cell membranes and clusters around neighboring cell corpses. CED-1 failed to cluster around cell corpses in mutants defective in the engulfment gene ced-7. Motifs in the intracellular domain of CED-1 known to interact with PTB and SH2 domains were necessary for engulfment but not for clustering. Our results indicate that CED-1 is a cell surface phagocytic receptor that recognizes cell corpses. We suggest that the ABC transporter CED-7 promotes cell corpse recognition by CED-1, possibly by exposing a phospholipid ligand on the surfaces of cell corpses.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/CED-7 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger,
http://linkedlifedata.com/resource/pubmed/chemical/Scarb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
12
|
|
pubmed:volume |
104
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
43-56
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11163239-ATP-Binding Cassette Transporters,
pubmed-meshheading:11163239-Alleles,
pubmed-meshheading:11163239-Animals,
pubmed-meshheading:11163239-Animals, Genetically Modified,
pubmed-meshheading:11163239-Apoptosis,
pubmed-meshheading:11163239-Caenorhabditis elegans,
pubmed-meshheading:11163239-Caenorhabditis elegans Proteins,
pubmed-meshheading:11163239-Cloning, Molecular,
pubmed-meshheading:11163239-Consensus Sequence,
pubmed-meshheading:11163239-Epidermal Growth Factor,
pubmed-meshheading:11163239-Membrane Proteins,
pubmed-meshheading:11163239-Molecular Sequence Data,
pubmed-meshheading:11163239-Mutation,
pubmed-meshheading:11163239-Phagocytosis,
pubmed-meshheading:11163239-Phenotype,
pubmed-meshheading:11163239-Protein Binding,
pubmed-meshheading:11163239-Receptors, Immunologic,
pubmed-meshheading:11163239-Receptors, Lipoprotein,
pubmed-meshheading:11163239-Receptors, Scavenger,
pubmed-meshheading:11163239-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:11163239-Scavenger Receptors, Class B,
pubmed-meshheading:11163239-Sequence Homology, Amino Acid,
pubmed-meshheading:11163239-Signal Transduction,
pubmed-meshheading:11163239-Transgenes,
pubmed-meshheading:11163239-src Homology Domains
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biology, Building 68, Room 425, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
