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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
A search for c-Abl interacting proteins resulted in the recovery of PSTPIP1, originally identified as a binding protein of the PEST-type protein tyrosine phosphatases (PTP). PSTPIP1 was phosphorylated by c-Abl, and growth factor-induced PSTPIP1 phosphorylation was diminished in Abl null fibroblasts. PSTPIP1 was able to bridge c-Abl to the PEST-type PTPs. Several experiments suggest that the PEST-type PTPs negatively regulate c-Abl activity: c-Abl was hyperphosphorylated in PTP-PEST-deficient cells; disruption of the c-Abl-PSTPIP1-PEST-type PTP ternary complex by overexpression of PSTPIP1 mutants increased c-Abl phosphotyrosine content; and PDGF-induced c-Abl kinase activation was prolonged in PTP-PEST-deficient cells. Dephosphorylation of c-Abl by PEST-type PTP represents a novel mechanism by which c-Abl activity is regulated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Pstpip1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn12 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1413-23
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11163214-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11163214-Animals,
pubmed-meshheading:11163214-COS Cells,
pubmed-meshheading:11163214-Carrier Proteins,
pubmed-meshheading:11163214-Cells, Cultured,
pubmed-meshheading:11163214-Cytoskeletal Proteins,
pubmed-meshheading:11163214-Enzyme Activation,
pubmed-meshheading:11163214-Epitopes,
pubmed-meshheading:11163214-Macromolecular Substances,
pubmed-meshheading:11163214-Mice,
pubmed-meshheading:11163214-Mutation,
pubmed-meshheading:11163214-Phosphorylation,
pubmed-meshheading:11163214-Phosphotyrosine,
pubmed-meshheading:11163214-Platelet-Derived Growth Factor,
pubmed-meshheading:11163214-Protein Binding,
pubmed-meshheading:11163214-Protein Tyrosine Phosphatase, Non-Receptor Type 12,
pubmed-meshheading:11163214-Protein Tyrosine Phosphatases,
pubmed-meshheading:11163214-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:11163214-Substrate Specificity,
pubmed-meshheading:11163214-Transfection,
pubmed-meshheading:11163214-Two-Hybrid System Techniques,
pubmed-meshheading:11163214-Yeasts,
pubmed-meshheading:11163214-src Homology Domains
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pubmed:year |
2000
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pubmed:articleTitle |
Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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