Source:http://linkedlifedata.com/resource/pubmed/id/11162868
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
A total of 29 previously untreated patients with histologically proven malignant pleural mesothelioma, with an ECOG score of < or = 2 and UICC stage I-II disease, were enrolled between May 1994 and October 1996. On days 1 and 2, 18 x 10(6) IU/day of rIL-2 was administered by continuous intravenous infusion, and 6 x 10(6) IU/day of rIL-2 by subcutaneous injection on days 5--20 inclusive of a 42-day cycle. Further treatment was administered if no radiological disease progression was demonstrated. A total of 29 patients were assessable for toxicity and 25 for response, and 49 cycles of IL-2 were administered with a median of one per patient (range, < 1-4). Toxicity included mild fever, nausea and vomiting, and skin rashes, < grade II. Three patients failed to complete one cycle of treatment because of toxicity and one died of disease before response evaluation. Two patients achieved a partial response (8%, 95% CI 1-26%) surviving 18.1 and 18.7 months from diagnosis. A total of 11 patients (44%, 95% CI 24-65%) with stable disease had a median survival of 13.6 months (range 6.5-33.8). The median survival was 8.6 months (range 3.7-34.5) for the 12 patients with progressive disease (48%, 95% CI 28-69%). This regimen of rIL-2 is well tolerated and shows limited activity in mesothelioma.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0169-5002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11162868-Adolescent,
pubmed-meshheading:11162868-Adult,
pubmed-meshheading:11162868-Aged,
pubmed-meshheading:11162868-Disease Progression,
pubmed-meshheading:11162868-Female,
pubmed-meshheading:11162868-Humans,
pubmed-meshheading:11162868-Infusions, Intravenous,
pubmed-meshheading:11162868-Injections, Subcutaneous,
pubmed-meshheading:11162868-Interleukin-2,
pubmed-meshheading:11162868-Male,
pubmed-meshheading:11162868-Mesothelioma,
pubmed-meshheading:11162868-Middle Aged,
pubmed-meshheading:11162868-Pleural Neoplasms,
pubmed-meshheading:11162868-Survival Analysis,
pubmed-meshheading:11162868-Treatment Outcome
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pubmed:year |
2001
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pubmed:articleTitle |
A phase II study of combined intravenous and subcutaneous interleukin-2 in malignant pleural mesothelioma.
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pubmed:affiliation |
Department of Medical Oncology, St. Bartholomew's Hospital, and the London NHS Trust, West Smithfield, London EC1A 7BE, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II
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