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rdf:type |
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lifeskim:mentions |
umls-concept:C0009017,
umls-concept:C0015576,
umls-concept:C0074129,
umls-concept:C0086418,
umls-concept:C0205245,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0680022,
umls-concept:C0907411,
umls-concept:C1423911,
umls-concept:C1880022
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pubmed:issue |
4
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pubmed:dateCreated |
2001-2-22
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pubmed:databankReference |
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pubmed:abstractText |
Using a human placenta cDNA library, we cloned a novel member belonging to the scavenger receptor family. Complementary DNA of this clone encodes a type II transmembranous glycoprotein containing a collagen-like domain, which are typical structural characteristics of scavenger receptor class A. This protein also contains a C-type lectin/carbohydrate recognition domain (C-type CRD) located at the C-terminus. We designated this as Scavenger Receptor with C-type Lectin (SRCL) type I. We also isolated human SRCL type II, which lacks the C-type CRD. Northern blot analysis revealed that hSRCL type I and type II mRNAs are abundantly expressed in adult human tissues. When hSRCL type I and type II were expressed in CHO-K1 cells, they were localized in the plasma membrane forming clusters on the surface. Ligand-binding studies of CHO-K1 cells expressing hSRCL type I and type II demonstrated their specific binding capacity in Escherichia coli and Staphylococcus aureus. These results indicate that hSRCL is a novel bacteria-binding receptor containing a C-type CRD and this receptor may play an important role in host defense.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Collectins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger,
http://linkedlifedata.com/resource/pubmed/chemical/Scarb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class A,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1028-35
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11162630-Amino Acid Sequence,
pubmed-meshheading:11162630-Animals,
pubmed-meshheading:11162630-Base Sequence,
pubmed-meshheading:11162630-Blotting, Northern,
pubmed-meshheading:11162630-CHO Cells,
pubmed-meshheading:11162630-Cell Membrane,
pubmed-meshheading:11162630-Chromosome Mapping,
pubmed-meshheading:11162630-Chromosomes, Human, Pair 18,
pubmed-meshheading:11162630-Cloning, Molecular,
pubmed-meshheading:11162630-Collagen,
pubmed-meshheading:11162630-Collectins,
pubmed-meshheading:11162630-Cricetinae,
pubmed-meshheading:11162630-DNA, Complementary,
pubmed-meshheading:11162630-Escherichia coli,
pubmed-meshheading:11162630-Gene Library,
pubmed-meshheading:11162630-Glycoproteins,
pubmed-meshheading:11162630-Humans,
pubmed-meshheading:11162630-Immunohistochemistry,
pubmed-meshheading:11162630-Ligands,
pubmed-meshheading:11162630-Membrane Proteins,
pubmed-meshheading:11162630-Microscopy, Fluorescence,
pubmed-meshheading:11162630-Models, Biological,
pubmed-meshheading:11162630-Molecular Sequence Data,
pubmed-meshheading:11162630-Placenta,
pubmed-meshheading:11162630-Precipitin Tests,
pubmed-meshheading:11162630-Protein Binding,
pubmed-meshheading:11162630-Protein Structure, Tertiary,
pubmed-meshheading:11162630-Receptors, Immunologic,
pubmed-meshheading:11162630-Receptors, Lipoprotein,
pubmed-meshheading:11162630-Receptors, Scavenger,
pubmed-meshheading:11162630-Scavenger Receptors, Class A,
pubmed-meshheading:11162630-Scavenger Receptors, Class B,
pubmed-meshheading:11162630-Sequence Homology, Amino Acid,
pubmed-meshheading:11162630-Staphylococcus aureus,
pubmed-meshheading:11162630-Tissue Distribution
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pubmed:year |
2001
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pubmed:articleTitle |
Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family.
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pubmed:affiliation |
Division of Biochemistry, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan. nakamura@onbich.med.osaka-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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