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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Mechanisms that protect most high-risk HIV-1 seronegative (HRSN) persons are not well understood. Among hemophiliacs from the Multicenter Hemophilia Cohort Study who remained HIV-1 seronegative despite a high (94%) risk for acquisition of HIV-1 infection, only 7/43 were homozygous for the protective CCR5 Delta32 polymorphism. Among the remainder, neither CCR5 density nor beta-chemokine production, nor in vitro susceptibility to infection with the HIV-1 isolate JR-FL could distinguish HRSN hemophiliacs from healthy controls. When compared to lymphocytes of healthy controls not at risk for HIV-1 infection, diminished spontaneous lymphocyte proliferation was seen in lymphocytes of HRSN hemophiliacs as well as in lymphocytes of hemophiliacs not at risk for HIV-1 infection. Surprisingly sera/plasmas obtained from high-risk HIV-1 seropositve hemophiliacs prior to seroconversion more often contained alloreactive antibodies than date-matched sera/plasmas obtained from HRSN hemophiliacs. Thus alloreactivity may predispose to acquisition of HIV-1 infection after parenteral exposure.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1521-6616
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pubmed:author |
pubmed-author:AledortLL,
pubmed-author:EysterM EME,
pubmed-author:GoedertJ JJJ,
pubmed-author:HilgartnerMM,
pubmed-author:KesslerCC,
pubmed-author:KonkleB ABA,
pubmed-author:LedermanM MMM,
pubmed-author:MeyersonHH,
pubmed-author:O'BrienT RTR,
pubmed-author:PurvisS FSF,
pubmed-author:SalkowitzJ RJR,
pubmed-author:WhiteG CGC2nd,
pubmed-author:ZimmermanPP
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
200-11
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11161976-Adolescent,
pubmed-meshheading:11161976-Adult,
pubmed-meshheading:11161976-Chemokine CCL4,
pubmed-meshheading:11161976-Chemokine CCL5,
pubmed-meshheading:11161976-Child,
pubmed-meshheading:11161976-Cohort Studies,
pubmed-meshheading:11161976-Drug Contamination,
pubmed-meshheading:11161976-Factor VIII,
pubmed-meshheading:11161976-Female,
pubmed-meshheading:11161976-Genetic Predisposition to Disease,
pubmed-meshheading:11161976-Genotype,
pubmed-meshheading:11161976-HIV Infections,
pubmed-meshheading:11161976-HIV Seronegativity,
pubmed-meshheading:11161976-HIV Seropositivity,
pubmed-meshheading:11161976-HIV-1,
pubmed-meshheading:11161976-Hemophilia A,
pubmed-meshheading:11161976-Hot Temperature,
pubmed-meshheading:11161976-Humans,
pubmed-meshheading:11161976-Immunity, Innate,
pubmed-meshheading:11161976-Isoantibodies,
pubmed-meshheading:11161976-Lymphocyte Activation,
pubmed-meshheading:11161976-Macrophage Inflammatory Proteins,
pubmed-meshheading:11161976-Male,
pubmed-meshheading:11161976-Polymorphism, Genetic,
pubmed-meshheading:11161976-Receptors, CCR5,
pubmed-meshheading:11161976-Risk
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pubmed:year |
2001
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pubmed:articleTitle |
Characterization of high-risk HIV-1 seronegative hemophiliacs.
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pubmed:affiliation |
Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Multicenter Study
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