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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Human parainfluenza virus type 3 (HPIV-3) is an airborne pathogen that infects the epithelial cells of the respiratory tract. In the present study we investigated the interaction of HPIV-3 with the type II alveolar human lung polarized epithelial A549 cells. Although HPIV-3 entry and budding were bidirectional from both the apical and the basolateral domains, HPIV-3 exhibited preferential entry and release from the apical pole. While disruption of the cellular actin microfilament and microtubule by cytochalasin D and nocodazole, respectively, had no effect on virus entry, disruption of the microtubule but not the microfilament inhibited HPIV-3 release.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-10073688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-10590141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-10819571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-1760930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-1851877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-215317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-2168957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-2672330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-4065093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-6088077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-6243354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-6314807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-6329709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-7761474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-7793085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-7884920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-7969453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-7997271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-8022774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-8391749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-8661384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-9525582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-9525606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-9576955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11160698-9916072
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1984-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
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pubmed:year |
2001
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pubmed:articleTitle |
Polarity of human parainfluenza virus type 3 infection in polarized human lung epithelial A549 cells: role of microfilament and microtubule.
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pubmed:affiliation |
Department of Virology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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