|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2001-2-22
|
|
pubmed:abstractText |
A small fraction of T cells expresses killer-cell Ig-like receptors (KIR), a family of MHC class I-specific receptors that can modulate TCR-dependent activation of effector functions. Although KIR(+) cells are enriched within Ag-experienced T cell subsets, the precise relationships between KIR(+) and KIR(-) T cells and the stage of KIR induction on these lymphocytes remain unclear. In this study, we compared KIR(-) and KIR(+) alphabeta T cell clones, sorted by means of the CD158b (KIR2DL2/KIR2DL3/KIR2DS2) specific mAb GL183. We isolated several pairs of CD158b(+) and CD158b(-) alphabeta T cell clones sharing identical productive and nonproductive TCR transcripts. We showed that expression of functional KIR on T cells is regulated after termination of TCR rearrangements. Transcriptional regulation of KIR genes was documented in multiple T cell clones generated from the same donor, and the presence of KIR transcripts was also detected in KIR(-) T cells. These results document a complex regulation of KIR expression in T cells at both pre and posttranscriptional levels, under the control of yet undefined signals provided in vivo.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/KIR2DL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KIR2DL3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR2DL2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, KIR2DL3
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
pubmed-author:BonnevilleMM,
pubmed-author:CouedelCC,
pubmed-author:DavodeauFF,
pubmed-author:HalaryFF,
pubmed-author:HoussaintEE,
pubmed-author:MorcetJJ,
pubmed-author:MorettaAA,
pubmed-author:PeyratMM,
pubmed-author:RomagneFF,
pubmed-author:SaulquinXX,
pubmed-author:SchleinitzNN,
pubmed-author:ScotetEE,
pubmed-author:VelyFF,
pubmed-author:VivierEE
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
166
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2487-94
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11160309-Amino Acid Sequence,
pubmed-meshheading:11160309-Animals,
pubmed-meshheading:11160309-COS Cells,
pubmed-meshheading:11160309-Cell Differentiation,
pubmed-meshheading:11160309-Cell Line,
pubmed-meshheading:11160309-Cell Line, Transformed,
pubmed-meshheading:11160309-Clone Cells,
pubmed-meshheading:11160309-Gene Expression Regulation,
pubmed-meshheading:11160309-Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,
pubmed-meshheading:11160309-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:11160309-Herpesvirus 4, Human,
pubmed-meshheading:11160309-Humans,
pubmed-meshheading:11160309-Lymphocyte Activation,
pubmed-meshheading:11160309-Molecular Sequence Data,
pubmed-meshheading:11160309-RNA Processing, Post-Transcriptional,
pubmed-meshheading:11160309-Reading Frames,
pubmed-meshheading:11160309-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:11160309-Receptors, Immunologic,
pubmed-meshheading:11160309-Receptors, KIR,
pubmed-meshheading:11160309-Receptors, KIR2DL2,
pubmed-meshheading:11160309-Receptors, KIR2DL3,
pubmed-meshheading:11160309-T-Lymphocyte Subsets,
pubmed-meshheading:11160309-Transcription, Genetic
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Regulation of inhibitory and activating killer-cell Ig-like receptor expression occurs in T cells after termination of TCR rearrangements.
|
|
pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale, Unité 463, Institut de Biologie, Nantes, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
