Source:http://linkedlifedata.com/resource/pubmed/id/11160067
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-2-22
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| pubmed:abstractText |
The purpose of the present study was to determine the responsiveness of airway vascular smooth muscle (AVSM) as assessed by airway mucosal blood flow (Qaw) to inhaled methoxamine (alpha(1)-agonist; 0.6-2.3 mg) and albuterol (beta(2)-agonist; 0.2-1.2 mg) in healthy [n = 11; forced expiratory volume in 1 s, 92 +/- 4 (SE) % of predicted] and asthmatic (n = 11, mean forced expiratory volume in 1 s, 81 +/- 5%) adults. Mean baseline values for Qaw were 43.8 +/- 0.7 and 54.3 +/- 0.8 microl. min(-1). ml(-1) of anatomic dead space in healthy and asthmatic subjects, respectively (P < 0.05). After methoxamine inhalation, the maximal mean change in Qaw was -13.5 +/- 1.0 microl. min(-1). ml(-1) in asthmatic and -7.1 +/- 2.1 microl. min(-1). ml(-1) in healthy subjects (P < 0.05). After albuterol, the mean maximal change in Qaw was 3.0 +/- 0.8 microl. min(-1). ml(-1) in asthmatic and 14.0 +/- 1.1 microl. min(-1). ml(-1) in healthy subjects (P < 0.05). These results demonstrate that the contractile response of AVSM to alpha(1)-adrenoceptor activation is enhanced and the dilator response of AVSM to beta(2)-adrenoceptor activation is blunted in asthmatic subjects.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
8750-7587
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
90
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
665-9
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11160067-Administration, Inhalation,
pubmed-meshheading:11160067-Adrenergic alpha-Agonists,
pubmed-meshheading:11160067-Adrenergic beta-Agonists,
pubmed-meshheading:11160067-Adult,
pubmed-meshheading:11160067-Albuterol,
pubmed-meshheading:11160067-Asthma,
pubmed-meshheading:11160067-Female,
pubmed-meshheading:11160067-Forced Expiratory Volume,
pubmed-meshheading:11160067-Humans,
pubmed-meshheading:11160067-Lung,
pubmed-meshheading:11160067-Male,
pubmed-meshheading:11160067-Methoxamine,
pubmed-meshheading:11160067-Middle Aged,
pubmed-meshheading:11160067-Muscle, Smooth, Vascular,
pubmed-meshheading:11160067-Pulmonary Circulation,
pubmed-meshheading:11160067-Respiratory Dead Space,
pubmed-meshheading:11160067-Respiratory Mucosa,
pubmed-meshheading:11160067-Vasoconstriction,
pubmed-meshheading:11160067-Vasodilation
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| pubmed:year |
2001
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| pubmed:articleTitle |
Adrenergic airway vascular smooth muscle responsiveness in healthy and asthmatic subjects.
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| pubmed:affiliation |
Division of Pulmonary and Critical Care Medicine, University of Miami School of Medicine at Mount Sinai Medical Center, Miami Beach, Florida 33140, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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