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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
The proton pump H(+),K(+)-adenosine triphosphatase (H(+),K(+)-ATPase) of parietal cells is the major humoral autoantigen in both human and experimental autoimmune gastritis (AIG) characterized by an inflammatory infiltrate in the gastric mucosa and loss of parietal cells. The aim of this study was to detect H(+),K(+)-ATPase-specific T cells in the gastric mucosa of patients with AIG and to define their functional properties.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:AmedeiAA,
pubmed-author:AppelmelkB JBJ,
pubmed-author:AzzurriAA,
pubmed-author:BenagianoMM,
pubmed-author:BerglanL RLR,
pubmed-author:CianchiFF,
pubmed-author:D'EliosM MMM,
pubmed-author:De PontJ JJJ,
pubmed-author:Del PreteGG,
pubmed-author:RomagnaniSS,
pubmed-author:Vandenbroucke-GraulsC MCM
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
377-86
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11159878-Adult,
pubmed-meshheading:11159878-Autoantigens,
pubmed-meshheading:11159878-Autoimmune Diseases,
pubmed-meshheading:11159878-B-Lymphocytes,
pubmed-meshheading:11159878-Biopsy,
pubmed-meshheading:11159878-Cell Death,
pubmed-meshheading:11159878-Clone Cells,
pubmed-meshheading:11159878-Epitopes,
pubmed-meshheading:11159878-Fas Ligand Protein,
pubmed-meshheading:11159878-Female,
pubmed-meshheading:11159878-Gastric Mucosa,
pubmed-meshheading:11159878-Gastritis,
pubmed-meshheading:11159878-H(+)-K(+)-Exchanging ATPase,
pubmed-meshheading:11159878-Humans,
pubmed-meshheading:11159878-Immunoglobulin G,
pubmed-meshheading:11159878-Membrane Glycoproteins,
pubmed-meshheading:11159878-Middle Aged,
pubmed-meshheading:11159878-Perforin,
pubmed-meshheading:11159878-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:11159878-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11159878-Th1 Cells
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pubmed:year |
2001
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pubmed:articleTitle |
H(+),K(+)-atpase (proton pump) is the target autoantigen of Th1-type cytotoxic T cells in autoimmune gastritis.
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pubmed:affiliation |
Department of Internal Medicine, University of Florence, Florence, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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