Source:http://linkedlifedata.com/resource/pubmed/id/11159745
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Targeting specific events associated with tumor development represents a rational approach to chemoprevention as well as therapeutic intervention. In this study the ability of difluoromethylornithine (DFMO) to inhibit UV-induced skin carcinogenesis when administered before or after the appearance of tumors was examined. SKH hairless mice were irradiated 3 times per week with 90 mJ/cm(2); this dose was increased by 10% weekly to a maximum of 175 mJ/cm(2). Mice supplied 0.4% DFMO in the drinking water continuously throughout the experiment had an average of 2.0 tumors/mouse (72% incidence) at 30 weeks while controls had an average of 8.2 tumors/mouse (100% incidence). DFMO started after 12 weeks of UV, a time prior to tumor appearance, yielded 3.6 tumors and 100% incidence at 30 weeks. Starting DFMO at 22 weeks, when an average of 2.5 tumors were present, caused regression of tumors for several weeks, followed by a slight rebound. The final tumor number at 30 weeks was 3.0 (96% incidence). Thus, DFMO has strong chemopreventive efficacy, as well as therapeutic activity, against UV-induced skin tumors. Histological and proliferative markers support this conclusion.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0143-3334
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11159745-Animals,
pubmed-meshheading:11159745-Anticarcinogenic Agents,
pubmed-meshheading:11159745-Antineoplastic Agents,
pubmed-meshheading:11159745-Cell Division,
pubmed-meshheading:11159745-Eflornithine,
pubmed-meshheading:11159745-Enzyme Induction,
pubmed-meshheading:11159745-Female,
pubmed-meshheading:11159745-Keratinocytes,
pubmed-meshheading:11159745-Mice,
pubmed-meshheading:11159745-Mice, Hairless,
pubmed-meshheading:11159745-Neoplasms, Radiation-Induced,
pubmed-meshheading:11159745-Ornithine Decarboxylase,
pubmed-meshheading:11159745-Skin,
pubmed-meshheading:11159745-Skin Neoplasms,
pubmed-meshheading:11159745-Ultraviolet Rays
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pubmed:year |
2001
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pubmed:articleTitle |
Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice.
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pubmed:affiliation |
The University of Texas MD Anderson Cancer Center, Science Park-Research Division, PO Box 389, Park Road 1C, Smithville, TX 78957, USA. sa83161@odin.mdacc.tmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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