| pubmed-article:11158965 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11158965 | lifeskim:mentions | umls-concept:C0034705 | lld:lifeskim |
| pubmed-article:11158965 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:11158965 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:11158965 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11158965 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11158965 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11158965 | pubmed:abstractText | We investigated the possible contribution of inducible nitric oxide synthase (iNOS) to postischemic heart dysfunction and injuries in stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP, 13-14 wk of age, had significantly higher systolic blood pressure and greater heart weight than age-matched Wistar-Kyoto rats (WKY). Permanent occlusion of the left anterior descending coronary artery (LAD) caused significant and long-lasting increases in the activity and mRNA expression of myocardial iNOS in SHRSP compared with WKY. However, there was no significant difference in the LAD occlusion-induced expression of interleukin-1beta mRNA between SHRSP and WKY. Hemodynamic deterioration and myocardial fibrosis were also observed in SHRSP at 4 wk after LAD occlusion. Continuous administration of 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT) completely blocked the LAD occlusion-induced increase in the myocardial iNOS activity of SHRSP. Moreover, postischemic heart dysfunction and injuries were also significantly ameliorated by 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT). These results suggest that the increased activity of myocardial iNOS plays a pivotal role in the development of postischemic cardiac dysfunction and injuries in SHRSP with the hypertensive and hypertrophic heart. | lld:pubmed |
| pubmed-article:11158965 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11158965 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11158965 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11158965 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11158965 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:11158965 | pubmed:author | pubmed-author:ItoTT | lld:pubmed |
| pubmed-article:11158965 | pubmed:author | pubmed-author:AbeKK | lld:pubmed |
| pubmed-article:11158965 | pubmed:author | pubmed-author:MuraeHH | lld:pubmed |
| pubmed-article:11158965 | pubmed:author | pubmed-author:TakashimaAA | lld:pubmed |
| pubmed-article:11158965 | pubmed:author | pubmed-author:IbiiNN | lld:pubmed |
| pubmed-article:11158965 | pubmed:author | pubmed-author:TokumuraMM | lld:pubmed |
| pubmed-article:11158965 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11158965 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:11158965 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11158965 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11158965 | pubmed:pagination | H668-73 | lld:pubmed |
| pubmed-article:11158965 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11158965 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11158965 | pubmed:articleTitle | Involvement of iNOS in postischemic heart dysfunction of stroke-prone spontaneously hypertensive rats. | lld:pubmed |
| pubmed-article:11158965 | pubmed:affiliation | Department of Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Co., Ltd., Toyonaka, Osaka 561-0825, Japan. kohji.abe@shionogi.co.jp | lld:pubmed |
| pubmed-article:11158965 | pubmed:publicationType | Journal Article | lld:pubmed |
