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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
We investigated the possible contribution of inducible nitric oxide synthase (iNOS) to postischemic heart dysfunction and injuries in stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP, 13-14 wk of age, had significantly higher systolic blood pressure and greater heart weight than age-matched Wistar-Kyoto rats (WKY). Permanent occlusion of the left anterior descending coronary artery (LAD) caused significant and long-lasting increases in the activity and mRNA expression of myocardial iNOS in SHRSP compared with WKY. However, there was no significant difference in the LAD occlusion-induced expression of interleukin-1beta mRNA between SHRSP and WKY. Hemodynamic deterioration and myocardial fibrosis were also observed in SHRSP at 4 wk after LAD occlusion. Continuous administration of 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT) completely blocked the LAD occlusion-induced increase in the myocardial iNOS activity of SHRSP. Moreover, postischemic heart dysfunction and injuries were also significantly ameliorated by 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT). These results suggest that the increased activity of myocardial iNOS plays a pivotal role in the development of postischemic cardiac dysfunction and injuries in SHRSP with the hypertensive and hypertrophic heart.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-5,6-dihydro-6-methyl-4H-1,3-...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazines
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0363-6135
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H668-73
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11158965-Animals,
pubmed-meshheading:11158965-Cardiomegaly,
pubmed-meshheading:11158965-Coronary Circulation,
pubmed-meshheading:11158965-Coronary Disease,
pubmed-meshheading:11158965-Enzyme Inhibitors,
pubmed-meshheading:11158965-Fetal Blood,
pubmed-meshheading:11158965-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:11158965-Interleukin-1,
pubmed-meshheading:11158965-Lipopolysaccharides,
pubmed-meshheading:11158965-Male,
pubmed-meshheading:11158965-Myocardial Ischemia,
pubmed-meshheading:11158965-Myocardium,
pubmed-meshheading:11158965-Nitric Oxide Synthase,
pubmed-meshheading:11158965-Nitric Oxide Synthase Type II,
pubmed-meshheading:11158965-Organ Size,
pubmed-meshheading:11158965-RNA, Messenger,
pubmed-meshheading:11158965-Rats,
pubmed-meshheading:11158965-Rats, Inbred SHR,
pubmed-meshheading:11158965-Rats, Inbred WKY,
pubmed-meshheading:11158965-Stroke,
pubmed-meshheading:11158965-Thiazines
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pubmed:year |
2001
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pubmed:articleTitle |
Involvement of iNOS in postischemic heart dysfunction of stroke-prone spontaneously hypertensive rats.
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pubmed:affiliation |
Department of Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Co., Ltd., Toyonaka, Osaka 561-0825, Japan. kohji.abe@shionogi.co.jp
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pubmed:publicationType |
Journal Article
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