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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Acute myeloid leukemia (AML) is a heterogeneous group of diseases. Normal cytogenetics (CN) constitutes the single largest group, while trisomy 8 (+8) as a sole abnormality is the most frequent trisomy. How trisomy contributes to tumorigenesis is unknown. We used oligonucleotide-based DNA microarrays to study global gene expression in AML+8 patients with +8 as the sole chromosomal abnormality and AML-CN patients. CD34(+) cells purified from normal bone marrow (BM) were also analyzed as a representative heterogeneous population of stem and progenitor cells. Expression patterns of AML patients were clearly distinct from those of CD34(+) cells of normal individuals. We show that AML+8 blasts overexpress genes on chromosome 8, estimated at 32% on average, suggesting gene-dosage effects underlying AML+8. Systematic analysis by cellular function indicated up-regulation of genes involved in cell adhesion in both groups of AML compared with CD34(+) blasts from normal individuals. Perhaps most interestingly, apoptosis-regulating genes were significantly down-regulated in AML+8 compared with AML-CN. We conclude that the clinical and cytogenetic heterogeneity of AML is due to fundamental biological differences.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10190284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10339463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10360372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10381639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10438727,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10446041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10521349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10610183,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10623880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10655065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10666684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10676951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10807786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10871842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10872463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10952317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-10963602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-2069907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-6300881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-6308654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-7834748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-7972015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8187069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8241503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8413235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8580810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8608018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8650192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8677752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8849440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8861966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8908518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-8913726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9044836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9045298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9045301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9204156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9226149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9426057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9607582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9746780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9784132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9843981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11158605-9915496
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1124-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11158605-Humans,
pubmed-meshheading:11158605-Leukemia, Myeloid,
pubmed-meshheading:11158605-Female,
pubmed-meshheading:11158605-Male,
pubmed-meshheading:11158605-Acute Disease,
pubmed-meshheading:11158605-Bone Marrow Cells,
pubmed-meshheading:11158605-Chromosome Mapping,
pubmed-meshheading:11158605-Trisomy,
pubmed-meshheading:11158605-Leukemia, Myeloid, Acute,
pubmed-meshheading:11158605-Reference Values,
pubmed-meshheading:11158605-Gene Expression Profiling,
pubmed-meshheading:11158605-Chromosomes, Human, Pair 8,
pubmed-meshheading:11158605-Antigens, CD34,
pubmed-meshheading:11158605-Polymerase Chain Reaction
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