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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017658,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0443146,
umls-concept:C1517004,
umls-concept:C1880022,
umls-concept:C2003941,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-22
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pubmed:databankReference |
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pubmed:abstractText |
The autoantigen in Goodpasture's disease is known to be the non-collagenous domain of the alpha3 chain of type IV collagen, alpha 3(IV)NC1. There is mounting evidence that alpha 3(IV)NC1 is also a target of autoimmunity in experimental autoimmune glomerulonephritis (EAG). Sado et al. [Kidney Int 1998; 53, 664-671] have reported that recombinant human alpha 3(IV)NC1 and alpha4(IV)NC1 are nephritogenic in WKY rats. We have proposed that immunization with homologous antigen is more appropriate for detailed investigation of autoimmunity in EAG.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0931-0509
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
253-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11158397-Albuminuria,
pubmed-meshheading:11158397-Amino Acid Sequence,
pubmed-meshheading:11158397-Animals,
pubmed-meshheading:11158397-Antibodies,
pubmed-meshheading:11158397-Autoantigens,
pubmed-meshheading:11158397-Autoimmune Diseases,
pubmed-meshheading:11158397-Base Sequence,
pubmed-meshheading:11158397-Collagen,
pubmed-meshheading:11158397-Collagen Type IV,
pubmed-meshheading:11158397-Creatinine,
pubmed-meshheading:11158397-Fibrin,
pubmed-meshheading:11158397-Glomerulonephritis,
pubmed-meshheading:11158397-Immunoglobulin G,
pubmed-meshheading:11158397-Kidney,
pubmed-meshheading:11158397-Male,
pubmed-meshheading:11158397-Molecular Sequence Data,
pubmed-meshheading:11158397-Rats,
pubmed-meshheading:11158397-Rats, Inbred WKY,
pubmed-meshheading:11158397-Recombinant Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
Expression and characterization of recombinant rat alpha 3(IV)NC1 and its use in induction of experimental autoimmune glomerulonephritis.
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pubmed:affiliation |
Renal Section, Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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