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rdf:type |
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lifeskim:mentions |
umls-concept:C0006413,
umls-concept:C0013139,
umls-concept:C0015576,
umls-concept:C0031437,
umls-concept:C0040648,
umls-concept:C0430054,
umls-concept:C0596988,
umls-concept:C0680022,
umls-concept:C1514623,
umls-concept:C1516451,
umls-concept:C1705053
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
The decapentaplegic (dpp) gene directs numerous developmental events in Drosophila melanogaster. dpp encodes a member of the Transforming Growth Factor-beta family of secreted signaling molecules. At this time, mechanisms of dpp signaling have not yet been fully described. Therefore we conducted a genetic screen for new dpp signaling pathway components. The screen exploited a transvection-dependent dpp phenotype: heldout wings. The screen generated 30 mutations that appear to disrupt transvection at dpp. One of the mutations is a translocation with a recessive lethal breakpoint in cytological region 23C1-2. Genetic analyses identified a number of mutations allelic to this breakpoint. The 23C1-2 complementation group includes several mutations in the newly discovered gene lilliputian (lilli). lilli mutations that disrupt the transvection-dependent dpp phenotype are also dominant maternal enhancers of recessive embryonic lethal alleles of dpp and screw. lilli zygotic mutant embryos exhibit a partially ventralized phenotype similar to dpp embryonic lethal mutations. Phylogenetic analyses revealed that lilli encodes the only Drosophila member of a family of transcription factors that includes the human genes causing Fragile-X mental retardation (FMR2) and Burkitt's Lymphoma (LAF4). Taken together, the genetic and phylogenetic data suggest that lilli may be an activator of dpp expression in embryonic dorsal-ventral patterning and wing development.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-10353905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-10409512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-10588740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-10655223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-10731132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-10767313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-1989880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-2120113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-2296575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-3447015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-3467201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-6804094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-6806814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-7705627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-7768443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-8330541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-8770593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-8852848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9205057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9233580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9272957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9299237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9475739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9502724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9529255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9636086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9808577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9810230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11156991-9827795
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fragile X Mental Retardation Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/dpp protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/lilliputian protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
717-25
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11156991-Alleles,
pubmed-meshheading:11156991-Amino Acid Sequence,
pubmed-meshheading:11156991-Animals,
pubmed-meshheading:11156991-Burkitt Lymphoma,
pubmed-meshheading:11156991-Chromosome Mapping,
pubmed-meshheading:11156991-Crosses, Genetic,
pubmed-meshheading:11156991-Drosophila Proteins,
pubmed-meshheading:11156991-Drosophila melanogaster,
pubmed-meshheading:11156991-Fragile X Mental Retardation Protein,
pubmed-meshheading:11156991-Gene Expression Regulation, Developmental,
pubmed-meshheading:11156991-Genes, Dominant,
pubmed-meshheading:11156991-Genes, Recessive,
pubmed-meshheading:11156991-Insect Proteins,
pubmed-meshheading:11156991-Models, Genetic,
pubmed-meshheading:11156991-Molecular Sequence Data,
pubmed-meshheading:11156991-Mutation,
pubmed-meshheading:11156991-Nerve Tissue Proteins,
pubmed-meshheading:11156991-Nuclear Proteins,
pubmed-meshheading:11156991-Phenotype,
pubmed-meshheading:11156991-Phylogeny,
pubmed-meshheading:11156991-RNA-Binding Proteins,
pubmed-meshheading:11156991-Signal Transduction,
pubmed-meshheading:11156991-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
A screen for modifiers of decapentaplegic mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt's Lymphoma family of transcription factors in Drosophila melanogaster.
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pubmed:affiliation |
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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