Source:http://linkedlifedata.com/resource/pubmed/id/11156688
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-1-26
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| pubmed:abstractText |
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome Type I (APS1), is an autosomal recessive autoimmune disease caused by mutations in a gene designated as AIRE (autoimmune regulator). Here we have studied the expression of Aire in transfected cell lines and in adult mouse tissues. Our results show that Aire has a dual subcellular location and that it is expressed in multiple immunologically relevant tissues such as the thymus, spleen, lymph nodes, and bone marrow. In addition, Aire expression was detected in various other tissues such as kidney, testis, adrenal glands, liver, and ovary. These findings suggest that APECED protein might also have a function(s) outside the immune system.(J Histochem Cytochem 49:197-208, 2001)
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-1554
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
49
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
197-208
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11156688-Animals,
pubmed-meshheading:11156688-Blotting, Western,
pubmed-meshheading:11156688-Cloning, Molecular,
pubmed-meshheading:11156688-Cricetinae,
pubmed-meshheading:11156688-DNA, Complementary,
pubmed-meshheading:11156688-Gene Expression,
pubmed-meshheading:11156688-Haplorhini,
pubmed-meshheading:11156688-Humans,
pubmed-meshheading:11156688-Immunohistochemistry,
pubmed-meshheading:11156688-In Situ Hybridization,
pubmed-meshheading:11156688-Mice,
pubmed-meshheading:11156688-Mutation,
pubmed-meshheading:11156688-Organ Specificity,
pubmed-meshheading:11156688-Polyendocrinopathies, Autoimmune,
pubmed-meshheading:11156688-RNA, Messenger,
pubmed-meshheading:11156688-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11156688-Subcellular Fractions,
pubmed-meshheading:11156688-Transcription Factors,
pubmed-meshheading:11156688-Transfection
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| pubmed:year |
2001
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| pubmed:articleTitle |
Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED).
|
| pubmed:affiliation |
Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|