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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2001-1-11
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pubmed:abstractText |
Vascular endothelial-cadherin (VE-cad) is an endothelial cell-specific adhesion molecule that is crucial for proper assembly of vascular tubes. Here we show that a monoclonal antibody (BV13) directed to the extracellular region of VE-cad inhibits formation of adherens junctions and capillary-like structures by endothelial cells and blocks angiogenesis in the mouse cornea and in Matrigel plugs in vivo. Systemic administration of BV13 markedly decreases the growth of s.c. Lewis lung or human A431 epidermoid tumors and strongly suppresses the growth of Lewis lung metastases. These data demonstrate that VE-cad is essential for postnatal angiogenesis and thus validate VE-cad as a novel target for antiangiogenesis agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/cadherin 5,
http://linkedlifedata.com/resource/pubmed/chemical/matrigel
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:BassiRR,
pubmed-author:BohlenPP,
pubmed-author:DejanaEE,
pubmed-author:HicklinD JDJ,
pubmed-author:HooperAA,
pubmed-author:LUMM,
pubmed-author:LiaoFF,
pubmed-author:MignattiPP,
pubmed-author:O'ConnorWW,
pubmed-author:OverholserJJ,
pubmed-author:SantiagoAA,
pubmed-author:ZanettiDD
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6805-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11156369-Animals,
pubmed-meshheading:11156369-Antibodies, Monoclonal,
pubmed-meshheading:11156369-Antigens, CD,
pubmed-meshheading:11156369-Antigens, CD31,
pubmed-meshheading:11156369-Cadherins,
pubmed-meshheading:11156369-Carcinoma, Lewis Lung,
pubmed-meshheading:11156369-Cell Adhesion,
pubmed-meshheading:11156369-Cell Division,
pubmed-meshheading:11156369-Collagen,
pubmed-meshheading:11156369-Cornea,
pubmed-meshheading:11156369-Dose-Response Relationship, Drug,
pubmed-meshheading:11156369-Drug Combinations,
pubmed-meshheading:11156369-Endothelium,
pubmed-meshheading:11156369-Humans,
pubmed-meshheading:11156369-Immunoglobulin G,
pubmed-meshheading:11156369-Immunohistochemistry,
pubmed-meshheading:11156369-In Situ Nick-End Labeling,
pubmed-meshheading:11156369-Laminin,
pubmed-meshheading:11156369-Lung Neoplasms,
pubmed-meshheading:11156369-Mice,
pubmed-meshheading:11156369-Mice, Nude,
pubmed-meshheading:11156369-Neoplasm Metastasis,
pubmed-meshheading:11156369-Neoplasm Transplantation,
pubmed-meshheading:11156369-Neovascularization, Pathologic,
pubmed-meshheading:11156369-Neovascularization, Physiologic,
pubmed-meshheading:11156369-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:11156369-Proteoglycans,
pubmed-meshheading:11156369-Time Factors,
pubmed-meshheading:11156369-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Monoclonal antibody to vascular endothelial-cadherin is a potent inhibitor of angiogenesis, tumor growth, and metastasis.
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pubmed:affiliation |
Department of Immunology, ImClone Systems Incorporated, New York, New York 10014, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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