Linked Life Data

11154757

Source:http://linkedlifedata.com/resource/pubmed/id/11154757

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-1-26
pubmed:abstractText
Although used widely in studies of naturally occurring cell death, systematic descriptions of the time course of changes in sensory neuron number and of limb innervation in the mouse are not available. The development of sensory innervation to the mouse forelimb was traced using the lipophilic carbocyanine dye, DiI, and correlated with neuron number in dorsal root ganglia contributing to the cervical enlargement. Axon invasion of the forelimb began at E10.5. Sensory axons reached the distal margin of the forelimb by E13.5. The difficulty of identifying immature neurons precluded estimating neuron numbers during the period of limb innervation. Neuron numbers in dorsal root ganglia (DRGs) C5-C8 increased from E14 to E16 and from E18 to P4. No evidence of a decline in neuron numbers was found during the developmental periods studied. Neuron number was compared in neonates and adults to determine if sensory neurons are added as body size increases as found in the frog [J. Comp. Neurol. 314 (1991) 106] and the rat [J. Comp. Neurol. 386 (1997) 8]. In contrast to previous findings, no difference was found in sensory neuron number between neonate and adult mice in either cervical or lumbar DRGs.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-30
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Developmental regulation of sensory neuron number and limb innervation in the mouse.
pubmed:affiliation
Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7545, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.