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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-1-29
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pubmed:abstractText |
Actinobacillus actinomycetemcomitans strains showing a 530-bp deletion in the promoter region of the leukotoxin gene operon elaborate high amounts of leukotoxin that may play a role in the pathogenesis of periodontal disease. This study used polymerase chain reaction detection to determine the occurrence of the 530-bp deletion in 94 A. actinomycetemcomitans strains from individuals of various ethnic backgrounds. Eleven blacks and one Hispanic subject but no Caucasian or Asian subjects showed the 530-bp deletion in the leukotoxin promoter region, suggesting that the deletion is mainly a characteristic of individuals of African descent. A. actinomycetemcomitans strains exhibiting a deletion in the leukotoxin promoter region occurred both in individuals having severe periodontitis and in adolescents revealing no evidence of destructive periodontal disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0902-0055
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
338-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11154428-Actinobacillus Infections,
pubmed-meshheading:11154428-Actinobacillus actinomycetemcomitans,
pubmed-meshheading:11154428-Adolescent,
pubmed-meshheading:11154428-Adult,
pubmed-meshheading:11154428-African Continental Ancestry Group,
pubmed-meshheading:11154428-Asian Continental Ancestry Group,
pubmed-meshheading:11154428-Bacterial Toxins,
pubmed-meshheading:11154428-Base Pairing,
pubmed-meshheading:11154428-Cytotoxins,
pubmed-meshheading:11154428-Ethnic Groups,
pubmed-meshheading:11154428-European Continental Ancestry Group,
pubmed-meshheading:11154428-Exotoxins,
pubmed-meshheading:11154428-Gene Deletion,
pubmed-meshheading:11154428-Gene Frequency,
pubmed-meshheading:11154428-Hispanic Americans,
pubmed-meshheading:11154428-Humans,
pubmed-meshheading:11154428-Operon,
pubmed-meshheading:11154428-Periodontal Diseases,
pubmed-meshheading:11154428-Periodontitis,
pubmed-meshheading:11154428-Polymerase Chain Reaction,
pubmed-meshheading:11154428-Promoter Regions, Genetic
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pubmed:year |
2000
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pubmed:articleTitle |
Frequency of 530-bp deletion in Actinobacillus actinomycetemcomitans leukotoxin promoter region.
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pubmed:affiliation |
Department of Periodontology, School of Dentistry, University of Southern California, Los Angeles, CA 90089-0641, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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