Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-1-29
pubmed:abstractText
The genes at the INK4A/ARF locus at 9p21 are frequently involved in human cancer. Virtually all p16(INK4A) exon 2 (henceforth called p16) inactivation in pediatric acute lymphoblastic leukemia (ALL) occurs by gene deletion. The results of this study illustrate that real-time quantitative polymerase chain reaction is capable of detecting gene deletion in primary patient specimens with a precision not previously achieved by conventional methods. Importantly, this assay includes the detection of hemizygous deletions. The study revealed, strikingly, that the risk ratio for relapse for hemizygous deletion compared with no deletion was 6.558 (P =.00687) and for homozygous deletion was 11.558 (P =.000539). These results confirm and extend the authors' previous findings that homozygous deletion of p16 in pediatric ALL patients is an independent prognostic indicator of outcome from therapy.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
572-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11154239-Actuarial Analysis, pubmed-meshheading:11154239-Adolescent, pubmed-meshheading:11154239-Bone Marrow, pubmed-meshheading:11154239-Carrier Proteins, pubmed-meshheading:11154239-Child, pubmed-meshheading:11154239-Child, Preschool, pubmed-meshheading:11154239-Cyclin-Dependent Kinase Inhibitor p16, pubmed-meshheading:11154239-Disease-Free Survival, pubmed-meshheading:11154239-Female, pubmed-meshheading:11154239-Gene Deletion, pubmed-meshheading:11154239-Genes, Tumor Suppressor, pubmed-meshheading:11154239-Genotype, pubmed-meshheading:11154239-Humans, pubmed-meshheading:11154239-Infant, pubmed-meshheading:11154239-Infant, Newborn, pubmed-meshheading:11154239-Male, pubmed-meshheading:11154239-Polymerase Chain Reaction, pubmed-meshheading:11154239-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:11154239-Predictive Value of Tests, pubmed-meshheading:11154239-Prognosis, pubmed-meshheading:11154239-Recurrence, pubmed-meshheading:11154239-Treatment Outcome
pubmed:year
2001
pubmed:articleTitle
Hemizygous p16(INK4A) deletion in pediatric acute lymphoblastic leukemia predicts independent risk of relapse.
pubmed:affiliation
Division of Children's Leukaemia and Cancer Research, TVWT Institute for Child Health Research, University of Western Australia, West Perth.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't