Linked Life Data

1115362

Source:http://linkedlifedata.com/resource/pubmed/id/1115362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1975-5-5
pubmed:abstractText
The effect of interference with central catecholamine- or serotonin-containing neurons on the response of rats to inhalation anesthetics were explored. Interference with catecholaminergic function by inhibition of amine synthesis with alpha-methyltyrosine alone or combined with destruction of these neurons by 6-hydroxydopamine reduced brain concentrations of norepinephrine and dopamine without altering serotonin concentrations. These alterations decreased the minimum alveolar concentration (MAC) of halothane when tail-clamping was used as the test stimulus. Similar small reductions of halothane MAC were produced in rats given 5,6-dihydroxytryptamine and p-chlorophenylalanine, which decreased brain serotonin without altering noreopinephrine or doapamine concentrations. When catecholaminergic or serotoninergic neuronal function was similarly disrupted in rats later exposed to cyclopropane, no alternation in MAC was observed. It is suggested that disruption of central amine-containing neurons may lower the MAC's of depressant anesthetics only, and not excitatory anesthetics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0003-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Central monaminergic neuronal effects on minimum alveolar concentrations (MAC) of halothane and cyclopropane in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.