Source:http://linkedlifedata.com/resource/pubmed/id/11153534
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2001-1-10
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| pubmed:abstractText |
1. Whole-genome scans have identified Dmo1 as a major quantitative trait locus for dyslipidaemia and obesity in the Otsuka Long Evans Tokushima Fatty (OLETF) rat. 2. We have produced congenic rats for the Dmo1 locus through successive back-cross breeding with diabetic OLETF rats. Marker-assisted speed congenic protocols were applied to efficiently transfer chromosomal segments from non-diabetic Brown Norway (BN) rats into the OLETF background. 3. In the fourth generation of congenic animals, we observed a substantial therapeutic effect of the Dmo1 locus on lipid metabolism, obesity control and plasma glucose homeostasis. 4. We have concluded that Dmo1 primarily affects lipid homeostasis, obesity control and/or glucose homeostasis at fasting and is secondarily involved in glucose homeostasis after loading. 5. The results of the present study show that single-allele correction of a genetic defect of the Dmo1 locus can generate a substantial therapeutic effect, despite the complex polygenic nature of type II diabetic syndromes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0305-1870
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| pubmed:author |
pubmed-author:AsaiTT,
pubmed-author:GotoYY,
pubmed-author:HayashiII,
pubmed-author:HishigakiHH,
pubmed-author:MiyaoHH,
pubmed-author:Mizoguchi-MiyakitaAA,
pubmed-author:MomotaHH,
pubmed-author:NakamuraYY,
pubmed-author:OgaKK,
pubmed-author:OkunoSS,
pubmed-author:OnoTT,
pubmed-author:ShinomiyaHH,
pubmed-author:SuzukiMM,
pubmed-author:TakagiTT,
pubmed-author:TanigamiAA,
pubmed-author:WakitaniSS,
pubmed-author:WatanabeT KTK,
pubmed-author:YamasakiYY
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| pubmed:issnType |
Print
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| pubmed:volume |
28
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
28-42
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11153534-Alleles,
pubmed-meshheading:11153534-Animals,
pubmed-meshheading:11153534-Animals, Congenic,
pubmed-meshheading:11153534-Blood Glucose,
pubmed-meshheading:11153534-Body Weight,
pubmed-meshheading:11153534-Chromosome Mapping,
pubmed-meshheading:11153534-Diabetes Mellitus, Type 2,
pubmed-meshheading:11153534-Hyperlipidemias,
pubmed-meshheading:11153534-Insulin,
pubmed-meshheading:11153534-Male,
pubmed-meshheading:11153534-Obesity,
pubmed-meshheading:11153534-Phenotype,
pubmed-meshheading:11153534-Rats,
pubmed-meshheading:11153534-Rats, Long-Evans
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| pubmed:articleTitle |
Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat.
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| pubmed:affiliation |
Otsuka GEN Research Institute, Otsuka Pharmaceutical Co. Ltd, Tokushima, Japan. watanabe@otsuka.gr.jp
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| pubmed:publicationType |
Journal Article
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