Linked Life Data

11151789

Source:http://linkedlifedata.com/resource/pubmed/id/11151789

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-1-9
pubmed:abstractText
Fibrin deposits are found in and around the vessels in transplant coronary artery disease, in spontaneous atherosclerosis, and in the microvasculature of failing cardiac allografts. Fibrin is deposited due to a failure in anticoagulant pathways, one of the most important being the heparan sulfate proteoglycan-antithrombin (AT) natural anticoagulant pathway. A failure in this pathway results in a loss of AT binding in veins and arteries and increased fibrin deposition. This is associated with an increased risk of coronary artery disease and graft failure. Recovery of the previously lost vascular AT binding is associated with the development of a novel binding of AT by capillaries. The development of capillary AT binding is associated with significantly less coronary artery disease and improved survival. Understanding the mechanisms involved in the development of this unusual binding of AT by capillaries is important in developing new treatments directed to promote microvascular AT binding and reduce the deposition of fibrin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5860
pubmed:author
pubmed:issnType
Print
pubmed:volume
89 Suppl 9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
IX/32-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Vascular anticoagulation and transplant coronary artery disease.
pubmed:affiliation
Methodist Research Institute, Clarian Health Partners, 1812 N. Capitol Avenue, Indianapolis, IN 46202, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't