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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-18
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pubmed:abstractText |
Bupivacaine-induced regeneration was studied in rat soleus muscle under several conditions, with the focus on type 2A and type 1 myosin heavy chain (MHC) isoform expression. In denervated muscles, type 1 was absent, whereas type 2A was widely expressed, a pattern of regeneration which appeared to be independent of fibrillation activity of the muscle. Both type 1 and type 2A isoforms were absent in muscles regenerated during tetrodotoxin (TTX) block of impulse conduction in the sciatic nerve, but type 2A was still present when the TTX block was associated with the vinblastine block of axoplasmic flow; vinblastine block alone caused the coexpression of type 1 and type 2A isoforms in the majority of fibers. These results suggest that axoplasmic flow carries some chemical factor that inhibits 2A MHC isoform expression. The results are also of clinical interest, contributing to the understanding of factors controlling muscle differentiation and adaptation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0148-639X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 John Wiley & Sons, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11150965-Anesthetics, Local,
pubmed-meshheading:11150965-Animals,
pubmed-meshheading:11150965-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11150965-Axonal Transport,
pubmed-meshheading:11150965-Bupivacaine,
pubmed-meshheading:11150965-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:11150965-Fasciculation,
pubmed-meshheading:11150965-Female,
pubmed-meshheading:11150965-Immunohistochemistry,
pubmed-meshheading:11150965-Male,
pubmed-meshheading:11150965-Muscle, Skeletal,
pubmed-meshheading:11150965-Muscle Denervation,
pubmed-meshheading:11150965-Muscle Fibers, Slow-Twitch,
pubmed-meshheading:11150965-Myosin Heavy Chains,
pubmed-meshheading:11150965-Procainamide,
pubmed-meshheading:11150965-Protein Isoforms,
pubmed-meshheading:11150965-Rats,
pubmed-meshheading:11150965-Rats, Wistar,
pubmed-meshheading:11150965-Regeneration,
pubmed-meshheading:11150965-Sciatic Nerve,
pubmed-meshheading:11150965-Tetrodotoxin,
pubmed-meshheading:11150965-Vinblastine
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pubmed:year |
2001
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pubmed:articleTitle |
Nerve control of type 2A MHC isoform expression in regenerating slow skeletal muscle.
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pubmed:affiliation |
Department of Human Anatomy and Physiology, Section of Physiology, University of Padua, Via Marzolo 3, 35131 Padova, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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