Linked Life Data

11150329

Source:http://linkedlifedata.com/resource/pubmed/id/11150329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-1-19
pubmed:abstractText
T-cell autoimmunity to myelin basic protein was recently shown to be neuroprotective in injured rat optic nerves. In the present study, using the mouse optic nerve, we examined whether active immunization rather than passive transfer of T-cells can be beneficial in protecting retinal ganglion cells (RGCs) from post-traumatic death. Before severe crush injury of the optic nerve, SJL/J and C3H.SW mice were actively immunized with encephalitogenic or nonencephalitogenic peptides of proteolipid protein (PLP) or myelin oligodendrocyte glycoprotein (MOG), respectively. At different times after the injury, the numbers of surviving RGCs in both strains immunized with the nonencephalitogenic peptides pPLP 190-209 or pMOG 1-22 were significantly higher than in injured controls treated with the non-self-antigen ovalbumin or with a peptide derived from beta-amyloid, a non-myelin-associated protein. Immunization with the encephalitogenic myelin peptide pPLP 139-151 was beneficial only when the disease it induced, experimental autoimmune encephalomyelitis, was mild. The results of this study show that survival of RGCs after axonal injury can be enhanced by vaccination with an appropriate self-antigen. Furthermore, the use of nonencephalitogenic myelin peptides for immunization apparently allows neuroprotection without incurring the risk of an autoimmune disease. Application of these findings might lead to a promising new approach for treating optic neuropathies such as glaucoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
136-42
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11150329-Animals, pubmed-meshheading:11150329-Cell Survival, pubmed-meshheading:11150329-Disease Models, Animal, pubmed-meshheading:11150329-Encephalomyelitis, Autoimmune, Experimental, pubmed-meshheading:11150329-Female, pubmed-meshheading:11150329-Fluorescent Dyes, pubmed-meshheading:11150329-Mice, pubmed-meshheading:11150329-Mice, Inbred Strains, pubmed-meshheading:11150329-Myelin Basic Proteins, pubmed-meshheading:11150329-Myelin Proteins, pubmed-meshheading:11150329-Myelin Proteolipid Protein, pubmed-meshheading:11150329-Myelin-Associated Glycoprotein, pubmed-meshheading:11150329-Nerve Crush, pubmed-meshheading:11150329-Optic Nerve Diseases, pubmed-meshheading:11150329-Optic Nerve Injuries, pubmed-meshheading:11150329-Peptide Fragments, pubmed-meshheading:11150329-Retinal Ganglion Cells, pubmed-meshheading:11150329-Stilbamidines, pubmed-meshheading:11150329-T-Lymphocytes, pubmed-meshheading:11150329-Vaccination
pubmed:year
2001
pubmed:articleTitle
Vaccination for neuroprotection in the mouse optic nerve: implications for optic neuropathies.
pubmed:affiliation
Departments of Neurobiology and Immunology, The Weizmann Institute of Science, Rehovot, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't