rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
11
|
pubmed:dateCreated |
2001-1-8
|
pubmed:abstractText |
This report describes two patients with germ cell tumors who underwent tandem autologous peripheral stem cell transplants. The chemotherapy consisted of high-dose carboplatin and etoposide. Both patients developed chemotherapy-related toxicities, which included nephrotoxicity in one case and febrile neutropenia, thrombocytopenia, ototoxicity and mucositis in both. During the second transplant, both patients received amifostine 15 min before and 2 h after each dose of carboplatin. The patients had less mucositis and nephrotoxicity. The duration of neutropenia and thrombocytopenia was less in both cases resulting in a decreased use of antibiotics and platelet transfusions. These cases suggest that the use of amifostine may be of benefit in minimizing toxicities associated with high-dose chemotherapy.
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0268-3369
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
26
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1247-9
|
pubmed:dateRevised |
2006-4-24
|
pubmed:meshHeading |
pubmed-meshheading:11149742-Adult,
pubmed-meshheading:11149742-Amifostine,
pubmed-meshheading:11149742-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11149742-Bleomycin,
pubmed-meshheading:11149742-Carboplatin,
pubmed-meshheading:11149742-Cisplatin,
pubmed-meshheading:11149742-Combined Modality Therapy,
pubmed-meshheading:11149742-Dose-Response Relationship, Drug,
pubmed-meshheading:11149742-Etoposide,
pubmed-meshheading:11149742-Germinoma,
pubmed-meshheading:11149742-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11149742-Humans,
pubmed-meshheading:11149742-Kidney Diseases,
pubmed-meshheading:11149742-Male,
pubmed-meshheading:11149742-Testicular Neoplasms,
pubmed-meshheading:11149742-Transplantation Conditioning
|
pubmed:year |
2000
|
pubmed:articleTitle |
Use of amifostine as a chemoprotectant during high-dose chemotherapy in autologous peripheral blood stem cell transplantation.
|
pubmed:affiliation |
Blood and Marrow Stem Cell Transplantation Program, College of Pharmacy, University of Michigan Medical Center, Ann Arbor, USA.
|
pubmed:publicationType |
Journal Article,
Case Reports
|