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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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|
pubmed:dateCreated |
2001-1-5
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pubmed:abstractText |
The French protocol LALA 87 was designed to compare three different postinduction strategies in adult acute lymphocytic leukemia (ALL): chemotherapy, autologous transplantation, and allogeneic transplantation. This trial demonstrated a significant superiority of allogeneic bone marrow transplantation (BMT) in high-risk ALL patients. Similarly, there was a trend in favor of autologous BMT over chemotherapy in those same patients. Allogeneic BMT was not superior to autologous BMT or chemotherapy in less aggressive leukemia (standard-risk ALL). Further improvements are warranted in the treatment of adult ALL. The authors' current ongoing study is stratifying patients to allocate them to regimens with risk-adapted treatment intensity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0889-8588
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1353-66, x
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11147227-Adolescent,
pubmed-meshheading:11147227-Adult,
pubmed-meshheading:11147227-Age Factors,
pubmed-meshheading:11147227-Aged,
pubmed-meshheading:11147227-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11147227-Belgium,
pubmed-meshheading:11147227-Bone Marrow Transplantation,
pubmed-meshheading:11147227-Clinical Trials as Topic,
pubmed-meshheading:11147227-Combined Modality Therapy,
pubmed-meshheading:11147227-France,
pubmed-meshheading:11147227-Humans,
pubmed-meshheading:11147227-Immunophenotyping,
pubmed-meshheading:11147227-Life Tables,
pubmed-meshheading:11147227-Middle Aged,
pubmed-meshheading:11147227-Multicenter Studies as Topic,
pubmed-meshheading:11147227-Philadelphia Chromosome,
pubmed-meshheading:11147227-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:11147227-Prognosis,
pubmed-meshheading:11147227-Remission Induction,
pubmed-meshheading:11147227-Risk Factors,
pubmed-meshheading:11147227-Salvage Therapy,
pubmed-meshheading:11147227-Survival Analysis,
pubmed-meshheading:11147227-Survival Rate,
pubmed-meshheading:11147227-Transplantation, Autologous,
pubmed-meshheading:11147227-Transplantation, Homologous,
pubmed-meshheading:11147227-Treatment Outcome
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pubmed:year |
2000
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pubmed:articleTitle |
Adult acute lymphocytic leukemia study testing chemotherapy and autologous and allogeneic transplantation. A follow-up report of the French protocol LALA 87.
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pubmed:affiliation |
Service d'Hématologie, Hôpital Edouard Herriot, Lyon, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Review,
Research Support, Non-U.S. Gov't
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