Linked Life Data

11146520

Source:http://linkedlifedata.com/resource/pubmed/id/11146520

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-2
pubmed:abstractText
Saphenous vein graft (SVG) intervention has been associated with an increased incidence of distal embolization. Long lesions and lesions associated with thrombus are particularly at increased risk. This study was performed to determine whether abciximab may decrease this risk in high risk SVG angioplasty. From June 1994 to June 1998, 84 patients with at least one high risk factor, i.e., lesion length >20 mm or angiographic evidence of thrombus, underwent Transluminal extraction atherectomy (TEC) procedure followed by balloon dilatation or stenting. Of these 84 patients, 37 who had procedure after September 1995 underwent TEC with abciximab (Abciximab Group) and 47 who had their procedure before that date had TEC without abciximab thereby serving as historic control (Non-Abciximab Group). All patients had normal pre-procedure CK and CK-MB. Total creatine kinase (CK) and CK-MB were measured every 8 hr post-procedure for 24 hr. Baseline demographics, angiographic characteristics, incidence of LV dysfunction and triple vessel disease were similar between the two groups. Graft age was similar between two groups (122 +/- 70 vs. 117 +/- 54 months). Graft diameter, pre and post-procedure percent stenoses were not different between the two groups. Stents were used in 65% in the Abciximab group and 45% in Non-Abciximab group (P = 0. 14). There was no in-hospital repeat PTCA, urgent bypass surgery, or cardiac death. There was no difference between the two groups in regards to the incidence of any elevation of total CK (27% vs. 21. 3%) or CK-MB (54% vs. 51%). When used in conjunction with TEC in treating high risk vein graft lesions, abciximab did not reduce post procedure CK-MB elevation in this patient population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1522-1946
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-4
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11146520-Aged, pubmed-meshheading:11146520-Angioplasty, Balloon, Coronary, pubmed-meshheading:11146520-Antibodies, Monoclonal, pubmed-meshheading:11146520-Atherectomy, pubmed-meshheading:11146520-Chi-Square Distribution, pubmed-meshheading:11146520-Coronary Angiography, pubmed-meshheading:11146520-Coronary Artery Bypass, pubmed-meshheading:11146520-Coronary Disease, pubmed-meshheading:11146520-Creatine Kinase, pubmed-meshheading:11146520-Creatine Kinase, MB Form, pubmed-meshheading:11146520-Female, pubmed-meshheading:11146520-Follow-Up Studies, pubmed-meshheading:11146520-Graft Occlusion, Vascular, pubmed-meshheading:11146520-Graft Rejection, pubmed-meshheading:11146520-Humans, pubmed-meshheading:11146520-Immunoglobulin Fab Fragments, pubmed-meshheading:11146520-Isoenzymes, pubmed-meshheading:11146520-Middle Aged, pubmed-meshheading:11146520-Platelet Aggregation Inhibitors, pubmed-meshheading:11146520-Probability, pubmed-meshheading:11146520-Risk Assessment, pubmed-meshheading:11146520-Saphenous Vein, pubmed-meshheading:11146520-Treatment Outcome
pubmed:year
2001
pubmed:articleTitle
Effect of abciximab on cardiac enzyme elevation after transluminal extraction atherectomy (TEC) in high-risk saphenous vein graft lesions: comparison with a historical control group.
pubmed:affiliation
Department of Medicine, Division of Cardiovascular Disease, The University of Alabama at Birmingham, 35294-0012m USA.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial