Source:http://linkedlifedata.com/resource/pubmed/id/11145704
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-1-26
|
| pubmed:abstractText |
IL-4 is a cytokine with anti-inflammatory properties on activated macrophages. Rheumatoid arthritis, an autoimmune inflammatory disease, is characterized by a paucity of IL-4 and an abundance of synovial macrophage-derived mediators. Herein, the effect of a single injection of adenovirus-producing rat IL-4 (AxCAIL-4) or a control virus with no inserted gene was compared with the effect of PBS injection into rat ankles. Ankles were injected before arthritis onset or at maximal inflammation. Preventatively, AxCAIL-4 reduced adjuvant-induced arthritis (AIA)- and/or AIA/adenoviral-induced ankle inflammation, decreasing articular index scores, ankle circumferences, paw volumes, radiographic scores, mean levels of monocyte chemoattractant protein-1, the number of inflammatory cells, and the number of synovial blood vessels. Therapeutically, AxCAIL-4 also decreased ankle circumferences and paw volumes in comparison with a control virus with no inserted gene and PBS groups. After arthritis onset, mean levels of TNF-alpha, IL-1beta, macrophage inflammatory protein-2, and RANTES were decreased in AxCAIL-4 rat ankle homogenates compared with PBS-treated homogenates. Thus, increased expression of IL-4 via gene therapy administered in a preventative and/or therapeutic manner reduced joint inflammation, synovial cellularity, levels of proinflammatory cytokines, vascularization, and bony destruction in rat AIA, suggesting that a similar treatment in humans may be beneficial.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-1767
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| pubmed:author |
pubmed-author:AminM AMA,
pubmed-author:AraiKK,
pubmed-author:ConnorsM AMA,
pubmed-author:HainesG KGK,
pubmed-author:KatschkeK JKJ,
pubmed-author:KochA EAE,
pubmed-author:KumarPP,
pubmed-author:KurataHH,
pubmed-author:RuszJ EJE,
pubmed-author:VolinM VMV,
pubmed-author:WoodruffD CDC,
pubmed-author:WoodsJ MJM
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
166
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1214-22
|
| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11145704-Adenoviruses, Human,
pubmed-meshheading:11145704-Animals,
pubmed-meshheading:11145704-Arthritis, Experimental,
pubmed-meshheading:11145704-Bone Resorption,
pubmed-meshheading:11145704-Chickens,
pubmed-meshheading:11145704-Cytokines,
pubmed-meshheading:11145704-Dose-Response Relationship, Immunologic,
pubmed-meshheading:11145704-Female,
pubmed-meshheading:11145704-Gene Therapy,
pubmed-meshheading:11145704-Genetic Vectors,
pubmed-meshheading:11145704-Hindlimb,
pubmed-meshheading:11145704-Humans,
pubmed-meshheading:11145704-Inflammation Mediators,
pubmed-meshheading:11145704-Injections, Intra-Articular,
pubmed-meshheading:11145704-Interleukin-4,
pubmed-meshheading:11145704-Mutagenesis, Insertional,
pubmed-meshheading:11145704-Neovascularization, Pathologic,
pubmed-meshheading:11145704-Rats,
pubmed-meshheading:11145704-Rats, Inbred Lew,
pubmed-meshheading:11145704-Viral Plaque Assay
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis.
|
| pubmed:affiliation |
Departments of. Medicine and Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|