Linked Life Data

11144672

Source:http://linkedlifedata.com/resource/pubmed/id/11144672

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2000-12-28
pubmed:abstractText
Coronary flow reserve is used to aid understanding why myocardial oxygen consumption may fail to meet demand. Its general aspects are well known, but the problems of using it are not. This manuscript describes three important factors that need to be considered when assessing coronary flow reserve. (1) Maximal flow is usually achieved by giving either increasing doses or else what is thought to be a maximal dose of a vasodilator, or by examining peak reactive hyperemia. Evidence that both these approaches are flawed is provided. (2) Existing methods in humans allow only total reserve to be determined, but this might be inadequate because changes in total reserve might not reflect changes in subendocardial flow reserve. (3) Because there is marked heterogeneity of flow reserve in the left ventricle, measuring total flow reserve does not indicate when small regions are becoming ischemic. More basic research is needed to overcome these difficulties.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0090-6964
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
884-96
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Problems of coronary flow reserve.
pubmed:affiliation
Department of Pediatrics and Cardiovascular Research Institute, University of California, San Francisco 94143, USA. jhoffman@pedcard.ucsf.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review