Linked Life Data

11143254

Source:http://linkedlifedata.com/resource/pubmed/id/11143254

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-12-15
pubmed:abstractText
The authors have developed a quality factor (QF) to compare gamma knife radiosurgery, linear accelerator radiosurgery, and intensity-modulated radiation therapy (IMRT) dosimetry. This QF relates the percentage of target covered (PTC) by the prescription radiation isodose, target volume (V(T)), and enclosed tissue volume, which receives greater than a particular dose (V(X)): QF(X) = PTCxV(T)/V(X). The authors investigated target shape independent of volume in predicting radiosurgical complication rates. Plastic targets of a defined volume (0.2, 0.5, 1.5, and 10 cm3) and four increasingly complex shapes (spherical, ellipsoid, simulated arteriovenous malformation [AVM], and horseshoe) were created. Dosimetry was studied on the Leksell GammaPlan, Adac/Pinnacle, and Nomos Corvus workstations. The dosimetry of a new 4 mm x 10-mm IMRT collimator array (the Nomos Beak) not yet validated for use in our clinical practice was studied. Particularly for larger targets, the gamma knife and IMRT Beak plans show similar conformality (QF assuming 15-Gy volume [QF15]). Particularly for small and round targets the gamma knife plan quality is significantly higher (QF assuming 12-Gy volume [QF12]). As V(T) and complexity increase, the IMRT Beak QF12 approaches that of the gamma knife. The QF12 of gamma knife dosimetry has an inverse correlation with target shape complexity independent of V(T). At a prescription dose of 15 Gy to the target margin, the QF15 is a conformality index. The 12-Gy volume (volume enclosed by 12-Gy surface/volume receiving at least 12 Gy) estimates the radiosurgical normal tissue complication rate for AVMs. When the target is well covered, the QF12 is inversely proportional to the complication risk and is a measure of the plan quality.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3085
pubmed:author
pubmed:issnType
Print
pubmed:volume
93 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
228-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
A quality factor to compare the dosimetry of gamma knife radiosurgery and intensity-modulated radiation therapy quantitatively as a function of target volume and shape. Technical note.
pubmed:affiliation
Department of Neurosurgery, Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts 02111, USA. jborden@mediaone.net
pubmed:publicationType
Journal Article, Comparative Study