Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-1-3
pubmed:abstractText
In total, 1218 Chinese from twelve ethnic groups and nine Han geographic groups were screened for the mtDNA 9-bp deletion motif. The frequency of the 9-bp deletion in all samples was 14.7% but ranged from 0% to 32% in the various ethnic groups. Three individuals had a triplication of the 9-bp segment. Phylogenetic and demographic analyses of the mtDNA hypervariable segment 1 (HVS 1) sequences suggest that the 9-bp deletion occurred more than once in China. The majority of the Chinese deletion haplotypes (about 90%) have a common origin as a mutational event following an initial expansion of modern humans in eastern Asia. Other deletion haplotypes and the three haplotypes with a 9-bp triplication may have arisen independently in the Chinese, presumably by replication error. HVS1 haplotype analysis suggests two possible migration routes of the 9-bp deletion in east and southeast Asia. Both migrations originated in China with one route leading to the Pacific Islands via Taiwan, the other to southeast Asia and possibly the Nicobar Islands. Along both routes of peopling, a decrease in HVSI diversity of the mtDNA haplotypes is observed. The "Polynesian motif (16217T/C, 16247A/G, and 16261C/T)" and the 16140T/C, 16266C/A, or C/G polymorphisms appear specific to each migration route.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0340-6717
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
504-12
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11140950-Asia, pubmed-meshheading:11140950-Asia, Southeastern, pubmed-meshheading:11140950-Asian Continental Ancestry Group, pubmed-meshheading:11140950-Base Pair Mismatch, pubmed-meshheading:11140950-Base Sequence, pubmed-meshheading:11140950-Biological Evolution, pubmed-meshheading:11140950-China, pubmed-meshheading:11140950-DNA, Mitochondrial, pubmed-meshheading:11140950-Emigration and Immigration, pubmed-meshheading:11140950-Ethnic Groups, pubmed-meshheading:11140950-Evolution, Molecular, pubmed-meshheading:11140950-Gene Frequency, pubmed-meshheading:11140950-Haplotypes, pubmed-meshheading:11140950-Humans, pubmed-meshheading:11140950-Molecular Sequence Data, pubmed-meshheading:11140950-Phylogeny, pubmed-meshheading:11140950-Polymorphism, Genetic, pubmed-meshheading:11140950-Sequence Deletion, pubmed-meshheading:11140950-Taiwan
pubmed:year
2000
pubmed:articleTitle
Evolutionary history of the mtDNA 9-bp deletion in Chinese populations and its relevance to the peopling of east and southeast Asia.
pubmed:affiliation
Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Yunnan.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't