Source:http://linkedlifedata.com/resource/pubmed/id/11137153
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2001-2-14
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pubmed:abstractText |
Recent studies on Schwann cells at the neuromuscular junction and non-synaptic regions of premyelinated axons indicate that extracellular ATP can act as an activity-dependent signaling molecule in communication between neurons and glia. Several mechanisms have been observed for the regulated release of ATP from synaptic and non-synaptic regions, and a diverse family of receptors for extracellular ATP has been characterized. The findings suggest functional consequences of neuron-glial communication beyond homeostasis of the extracellular environment surrounding neurons, including regulating synaptic strength, gene expression, mitotic rate, and differentiation of glia according to impulse activity in neural circuits.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0166-2236
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
625-33
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11137153-Action Potentials,
pubmed-meshheading:11137153-Adenosine Triphosphate,
pubmed-meshheading:11137153-Animals,
pubmed-meshheading:11137153-Ganglia, Spinal,
pubmed-meshheading:11137153-Humans,
pubmed-meshheading:11137153-Neuroglia,
pubmed-meshheading:11137153-Neurons,
pubmed-meshheading:11137153-Receptors, Purinergic,
pubmed-meshheading:11137153-Signal Transduction,
pubmed-meshheading:11137153-Synapses
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pubmed:year |
2000
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pubmed:articleTitle |
ATP: an extracellular signaling molecule between neurons and glia.
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pubmed:affiliation |
Neurocytology and Physiology Unit, Laboratory of Developmental Neurobiology at the National Institutes of Health, NICHD, Bldg 49, Room 5A38, 49 Convent Drive, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Review
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