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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-1-10
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pubmed:abstractText |
Secreted morphogens such as the Drosophila TGF-beta homolog Decapentaplegic (Dpp) are thought to spread through target tissues and form long-range concentration gradients providing positional information. Using a GFP-Dpp fusion, we monitored a TGF-beta family member trafficking in situ throughout the target tissue and forming a long-range concentration gradient. Evidence is presented that long-range Dpp movement involves Dpp receptor and Dynamin functions. We also show that the rates of endocytic trafficking and degradation determine Dpp signaling range. We propose a model where the gradient is formed via intracellular trafficking initiated by receptor-mediated endocytosis of the ligand in receiving cells with the gradient slope controlled by endocytic sorting of Dpp toward recycling versus degradation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dynamins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/dpp protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/rab GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
981-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11136982-Animals,
pubmed-meshheading:11136982-Animals, Genetically Modified,
pubmed-meshheading:11136982-Body Patterning,
pubmed-meshheading:11136982-Drosophila Proteins,
pubmed-meshheading:11136982-Drosophila melanogaster,
pubmed-meshheading:11136982-Dynamins,
pubmed-meshheading:11136982-Endocytosis,
pubmed-meshheading:11136982-Endosomes,
pubmed-meshheading:11136982-GTP Phosphohydrolases,
pubmed-meshheading:11136982-Genes, Reporter,
pubmed-meshheading:11136982-Green Fluorescent Proteins,
pubmed-meshheading:11136982-Immunohistochemistry,
pubmed-meshheading:11136982-Insect Proteins,
pubmed-meshheading:11136982-Luminescent Proteins,
pubmed-meshheading:11136982-Protein Transport,
pubmed-meshheading:11136982-Recombinant Fusion Proteins,
pubmed-meshheading:11136982-Temperature,
pubmed-meshheading:11136982-Transforming Growth Factor beta,
pubmed-meshheading:11136982-Wing,
pubmed-meshheading:11136982-rab GTP-Binding Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
Gradient formation of the TGF-beta homolog Dpp.
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pubmed:affiliation |
Max-Planck-Institut für molekulare Zellbiologie und Genetik Pfotenhauerstrasse, 108 D-01307, Dresden, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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