Source:http://linkedlifedata.com/resource/pubmed/id/11135676
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2001-1-12
|
| pubmed:databankReference | |
| pubmed:abstractText |
The 3.0 A resolution crystal structure of Pariacoto virus (PaV) reveals extensive interactions between portions of the viral RNA genome and the icosahedral capsid. Under the protein shell of the T = 3 quasi equivalent capsid lies a dodecahedral cage composed of RNA duplex that accounts for approximately 35% of the single-stranded RNA genome. The highly basic N-terminal regions (residues 7-54) of the subunits, forming pentamers (A subunits) are clearly visible in the density map and make numerous interactions with the RNA cage. The C-terminal segments (residues 394-401) of the A subunits lie in channels near the quasi three-fold axes. Electron cryo-microscopy and image reconstruction of PaV particles clearly show the dodecahedral RNA cage.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1072-8368
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
77-83
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11135676-Amino Acid Sequence,
pubmed-meshheading:11135676-Animals,
pubmed-meshheading:11135676-Capsid,
pubmed-meshheading:11135676-Cryoelectron Microscopy,
pubmed-meshheading:11135676-Crystallography, X-Ray,
pubmed-meshheading:11135676-Genome, Viral,
pubmed-meshheading:11135676-Insect Viruses,
pubmed-meshheading:11135676-Models, Molecular,
pubmed-meshheading:11135676-Molecular Sequence Data,
pubmed-meshheading:11135676-Mutation,
pubmed-meshheading:11135676-Nucleic Acid Conformation,
pubmed-meshheading:11135676-Protein Structure, Quaternary,
pubmed-meshheading:11135676-Protein Structure, Secondary,
pubmed-meshheading:11135676-Protein Subunits,
pubmed-meshheading:11135676-RNA, Viral,
pubmed-meshheading:11135676-RNA Viruses,
pubmed-meshheading:11135676-Sequence Alignment,
pubmed-meshheading:11135676-Spodoptera
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
The structure of pariacoto virus reveals a dodecahedral cage of duplex RNA.
|
| pubmed:affiliation |
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|