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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0007634,
umls-concept:C0033684,
umls-concept:C0039194,
umls-concept:C0245662,
umls-concept:C0425152,
umls-concept:C0443199,
umls-concept:C0814999,
umls-concept:C0851285,
umls-concept:C1517806,
umls-concept:C1539477
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pubmed:issue |
3
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pubmed:dateCreated |
2001-1-26
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pubmed:abstractText |
CD95 engagement results in apoptosis in thymocytes and in the Jurkat human leukemic T cell line. Biochemical analyses in CD95-engaged thymocytes and Jurkat cells revealed dysregulation of the G1/S cell cycle control point. Cyclin E was upregulated upon CD95 engagement, suggesting G1-to-S progression, but there was no upregulation of cyclin A. Instead, cyclin E was degraded by caspases. In addition, c-myc that normally acts on S-phase progression through the activation of cdc25A appeared to be involved in the inhibition of S-phase progression after CD95 ligation. This implies that G1-->S progression and apoptosis are intimately linked in cells undergoing CD95 ligation. Furthermore, our data suggest that CD95-induced apoptosis occurs at the G1/S phase transition. We therefore suggest that CD95 engagement not only triggers death signals but also affects the G1/S checkpoint.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0730-2312
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
328-38
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11135362-Amino Acid Chloromethyl Ketones,
pubmed-meshheading:11135362-Animals,
pubmed-meshheading:11135362-Antigens, CD95,
pubmed-meshheading:11135362-Apoptosis,
pubmed-meshheading:11135362-Caspases,
pubmed-meshheading:11135362-Cell Cycle Proteins,
pubmed-meshheading:11135362-Cell Separation,
pubmed-meshheading:11135362-Cells, Cultured,
pubmed-meshheading:11135362-Cysteine Proteinase Inhibitors,
pubmed-meshheading:11135362-Flow Cytometry,
pubmed-meshheading:11135362-G1 Phase,
pubmed-meshheading:11135362-Gene Expression Regulation,
pubmed-meshheading:11135362-Humans,
pubmed-meshheading:11135362-Jurkat Cells,
pubmed-meshheading:11135362-Mice,
pubmed-meshheading:11135362-Mice, Inbred CBA,
pubmed-meshheading:11135362-S Phase,
pubmed-meshheading:11135362-Thymus Gland
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pubmed:year |
2001
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pubmed:articleTitle |
Differential regulation of cell cycle-related proteins by CD95 engagement in thymocytes and T cell leukemic cell line, Jurkat.
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pubmed:affiliation |
The Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. pshoe@plaza.snu.ac.kr
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pubmed:publicationType |
Journal Article
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