pubmed:abstractText |
The obese Zucker rat exhibits insulin resistance, develops nephropathy at an early age, and may be a model of diabetic nephropathy. Dehydroepiandrosterone (DHEA) may ameliorate many of the factors that contribute to diabetic nephropathy, while angiotensin-converting enzyme inhibitors are known to be effective. One marker of nephropathy is the expression of alpha-smooth muscle actin.
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pubmed:affiliation |
Section of Endocrinology and Section of Nephrology, Department of Medicine, and Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-2822, USA. richards@lsuhsc.edu
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