Linked Life Data

11134586

Source:http://linkedlifedata.com/resource/pubmed/id/11134586

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-27
pubmed:abstractText
Quantitative autoradiography of benzodiazepine (BZ) receptors and competitive reverse transcription-polymerase chain reaction were used to characterize changes in BZ binding and GABA(A) receptor subunit transcription levels associated with the anxiolytic effects of alprazolam. Effects were assessed on punished and non-suppressed water consumption using a lick suppression (Vogel) paradigm. Alprazolam had no effect on non-suppressed licking, [(3)H]Ro 15-1788 binding or receptor subunit transcript levels, compared to non-drug controls. When each fifth lick produced a shock (0-0.5 mA), responding was suppressed in an intensity-related manner. The highest intensity significantly decreased licking (85%), [(3)H]Ro 15-1788 binding (12%) and alpha1 transcript levels (63%) in the basolateral nucleus of the amygdala, and [(3)H]Ro 15-1788 binding in the mediodorsal thalamic nucleus (15%), compared to non-punished controls. Punishment increased the ratio of gamma2L/S transcripts in the basolateral nucleus of the amygdala. Alprazolam blocked or reversed each of these effects. These results show that punishment has similar effects on BZ binding and GABA(A) receptor subunit expression and that alprazolam can block or reverse those effects. Such changes may be related to the anxiolytic effects of alprazolam.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
887
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Regulation of benzodiazepine receptor binding and GABA(A) subunit mRNA expression by punishment and acute alprazolam administration.
pubmed:affiliation
Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center in Shreveport, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't