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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-1-4
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pubmed:abstractText |
Adenovirus infection inhibits synthesis and processing of rRNA and redistributes nucleolar antigens. Adenovirus protein V associates with nucleoli in infected cells. This study delineates regions of protein V independently capable of nucleolar targeting. Also, evidence is presented that protein V has the unique property of relocating nucleolin and B23 to the cytoplasm when transiently expressed on its own in uninfected cells. Point mutation analysis indicates a role for the C terminus of protein V in the redirection of nucleolin and B23 to the cytoplasm. This is the first time an adenovirus protein has been shown to have a direct effect on nucleolar antigens in isolation from viral infection. Moreover, adenovirus protein V is the first protein demonstrated to be capable of redirecting nucleolin and B23 to the cytoplasm.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11134316-10036227,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11134316-9742256
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1031-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11134316-Adenovirus Infections, Human,
pubmed-meshheading:11134316-Adenoviruses, Human,
pubmed-meshheading:11134316-Amino Acid Sequence,
pubmed-meshheading:11134316-Cell Nucleolus,
pubmed-meshheading:11134316-Cytoplasm,
pubmed-meshheading:11134316-HeLa Cells,
pubmed-meshheading:11134316-Humans,
pubmed-meshheading:11134316-Molecular Sequence Data,
pubmed-meshheading:11134316-Nuclear Proteins,
pubmed-meshheading:11134316-Phosphoproteins,
pubmed-meshheading:11134316-Protein Transport,
pubmed-meshheading:11134316-RNA-Binding Proteins,
pubmed-meshheading:11134316-Recombinant Fusion Proteins,
pubmed-meshheading:11134316-Transfection,
pubmed-meshheading:11134316-Viral Core Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
Adenovirus protein V induces redistribution of nucleolin and B23 from nucleolus to cytoplasm.
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pubmed:affiliation |
Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Leeds LS9 7TF, United Kingdom. meddam@stjames.leeds.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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