Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-8
pubmed:abstractText
To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating that GH and IGF1 promote postnatal growth by both independent and common functions, as the growth retardation of double Ghr/Igf1 nullizygotes is more severe than that observed with either class of single mutant. In fact, the body weight of these double-mutant mice is only approximately 17% of normal and, in absolute magnitude ( approximately 5 g), only twice that of the smallest known mammal. Thus, the growth control pathway in which the components of the GH/IGF1 signaling systems participate constitutes the major determinant of body size. To complement this conclusion mainly based on extensive growth curve analyses, we also present details concerning the involvement of the GH/IGF1 axis in linear growth derived by a developmental study of long bone ossification in the mutants.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0012-1606
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Academic Press.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
229
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11133160-Animals, pubmed-meshheading:11133160-Base Sequence, pubmed-meshheading:11133160-Body Constitution, pubmed-meshheading:11133160-Bone Development, pubmed-meshheading:11133160-Endocrine Glands, pubmed-meshheading:11133160-Gene Expression Regulation, pubmed-meshheading:11133160-Growth, pubmed-meshheading:11133160-Growth Hormone, pubmed-meshheading:11133160-Insulin-Like Growth Factor I, pubmed-meshheading:11133160-Mice, pubmed-meshheading:11133160-Mice, Mutant Strains, pubmed-meshheading:11133160-Molecular Sequence Data, pubmed-meshheading:11133160-Mutagenesis, pubmed-meshheading:11133160-Organ Size, pubmed-meshheading:11133160-RNA, Messenger, pubmed-meshheading:11133160-Receptors, Somatotropin, pubmed-meshheading:11133160-Signal Transduction, pubmed-meshheading:11133160-Tissue Distribution
pubmed:year
2001
pubmed:articleTitle
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.
pubmed:affiliation
Department of Genetics and Development, Columbia University, New York, New York 10032, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.