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rdf:type |
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lifeskim:mentions |
umls-concept:C0016059,
umls-concept:C0022646,
umls-concept:C0034693,
umls-concept:C0205263,
umls-concept:C0268790,
umls-concept:C0332206,
umls-concept:C0597357,
umls-concept:C0857121,
umls-concept:C1414262,
umls-concept:C1720127,
umls-concept:C2348358
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pubmed:issue |
12
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pubmed:dateCreated |
2000-12-29
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pubmed:abstractText |
In two kidney-one clip renovascular hypertension (2K1C), blood flow is reduced in the clipped kidney leading to ischaemia. The non-clipped kidney is characterized by increased shear stress. Circulating Ang II is elevated. All these factors are stimuli of the paracrine renal endothelin system. Indeed, we demonstrated an activation of the renal endothelin system in the 2K1C rat model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0263-6352
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1807-14
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11132605-Animals,
pubmed-meshheading:11132605-Atrophy,
pubmed-meshheading:11132605-Creatinine,
pubmed-meshheading:11132605-Fibrosis,
pubmed-meshheading:11132605-Hypertension, Renal,
pubmed-meshheading:11132605-Kidney,
pubmed-meshheading:11132605-Male,
pubmed-meshheading:11132605-Organ Size,
pubmed-meshheading:11132605-Peptides, Cyclic,
pubmed-meshheading:11132605-Rats,
pubmed-meshheading:11132605-Rats, Inbred WKY,
pubmed-meshheading:11132605-Receptor, Endothelin A,
pubmed-meshheading:11132605-Receptors, Endothelin,
pubmed-meshheading:11132605-Renin
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pubmed:year |
2000
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pubmed:articleTitle |
ETA receptor blockade induces fibrosis of the clipped kidney in two-kidney-one-clip renovascular hypertensive rats.
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pubmed:affiliation |
Department of Nephrology, Universitätsklinikum Charité der Humboldt Universität zu Berlin, Germany. berthold.hocher@rz.hu-berlin-de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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