Linked Life Data

11131916

Source:http://linkedlifedata.com/resource/pubmed/id/11131916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-12-22
pubmed:abstractText
Previous work suggests that neutrophils (PMNs) and/or prostaglandins might mediate the progressive respiratory failure after severe pulmonary contusion. Since reactive oxygen metabolites are closely associated with both these factors, we examined the actions of a novel antioxidant after swine received a unilateral injury followed by 25% hemorrhage. An infusion (2mL/kg/h intravenously x 6 h) of either polynitroxylated 5% Dextran + Tempol (PND, n = 9), 5% Dextran (D, n = 6), or lactated Ringers (LR, n = 13) was begun 60 min post-injury to mimic 'pre-hospital resuscitation.' After 15 min, standard resuscitation was initiated (3x shed blood as LR in 30 min) plus further LR for 6 h to maintain hemodynamics. The total LR requirement was lower with PND (1,772+/-267 mL) versus D (3,040+/-689, P = 0.0563) or LR (4145+/-398, P = 0.0005). The ipsilateral bronchoalveolar lavage (BAL) PMN count with PND (8+/-2 x 10(5)/mL), was not different from its baseline (P = 0.131), but the counts with D (16+/-3) and LR (17+/-4) were both higher than their baselines (P = 0.0184 and 0.0431). Similarly, BAL protein with PND (1,560+/-350 mg %) was not elevated from its baseline (P = 0.0721), but the values with D (2,560+/-498) and LR (2,474+/-899) were both higher than their baselines (P = 0.0169 and 0.0325). In the contralateral (uninjured) lung, the effects were similar, but the increases were less for PMNs (8+/-2 versus 10+/-2 or 14+/-4 x 10(5)/mL) and for protein (609 +/-153 versus 1,955+/-671 or 1486+/-357 mg %). Despite these significant BAL changes, there was no obvious improvement in cardiopulmonary dysfunction. Thus oxidants probably have some role in the pathogenic mechanism of progressive secondary injury after thoracic trauma, but further work is needed to determine the therapeutic potential of antioxidants because no clinical improvement was detected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1073-2322
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
646-51
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11131916-Animals, pubmed-meshheading:11131916-Antioxidants, pubmed-meshheading:11131916-Bronchoalveolar Lavage Fluid, pubmed-meshheading:11131916-Cell Count, pubmed-meshheading:11131916-Cyclic N-Oxides, pubmed-meshheading:11131916-Dextrans, pubmed-meshheading:11131916-Disease Models, Animal, pubmed-meshheading:11131916-Female, pubmed-meshheading:11131916-Hemodynamics, pubmed-meshheading:11131916-Isotonic Solutions, pubmed-meshheading:11131916-Lung, pubmed-meshheading:11131916-Lung Injury, pubmed-meshheading:11131916-Male, pubmed-meshheading:11131916-Neutrophils, pubmed-meshheading:11131916-Proteins, pubmed-meshheading:11131916-Resuscitation, pubmed-meshheading:11131916-Shock, Hemorrhagic, pubmed-meshheading:11131916-Spin Labels, pubmed-meshheading:11131916-Swine, pubmed-meshheading:11131916-Thoracic Injuries, pubmed-meshheading:11131916-Wounds, Nonpenetrating
pubmed:year
2000
pubmed:articleTitle
Effects of a novel antioxidant during resuscitation from severe blunt chest trauma.
pubmed:affiliation
Department of Surgery and Physiology, University of Tennessee Health Science Center, Memphis 38163, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.